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Mulè A, Bruno E, Pasanisi P, et al. Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome. Front Physiol. 2021;12:641461doi: 10.3389/fphys.2021.641461.
Mulè, A., Bruno, E., Pasanisi, P., Galasso, L., Castelli, L., Caumo, A., Esposito, F., Roveda, E., & Montaruli, A. (2021). Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome. Frontiers in physiology, 12641461. https://doi.org/10.3389/fphys.2021.641461
Mulè, Antonino, et al. "Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome." Frontiers in physiology vol. 12 (2021): 641461. doi: https://doi.org/10.3389/fphys.2021.641461
Mulè A, Bruno E, Pasanisi P, Galasso L, Castelli L, Caumo A, Esposito F, Roveda E, Montaruli A. Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome. Front Physiol. 2021 Mar 18;12:641461. doi: 10.3389/fphys.2021.641461. eCollection 2021. PMID: 33815145; PMCID: PMC8013705.
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Front Physiol. 2021 Mar 18;12:641461. doi: 10.3389/fphys.2021.641461. eCollection 2021.

Sex Differences in Rest-Activity Circadian Rhythm in Patients With Metabolic Syndrome.

Frontiers in physiology

Antonino Mulè, Eleonora Bruno, Patrizia Pasanisi, Letizia Galasso, Lucia Castelli, Andrea Caumo, Fabio Esposito, Eliana Roveda, Angela Montaruli

Affiliations

  1. Department of Biomedical Sciences for Health, University of Milan, Milan, Italy.
  2. Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.
  3. IRCCS, Istituto Ortopedico Galeazzi, Milan, Italy.

PMID: 33815145 PMCID: PMC8013705 DOI: 10.3389/fphys.2021.641461

Abstract

Rest-Activity circadian Rhythm (RAR) can be used as a marker of the circadian timing system. Recent studies investigated the relationship between irregular circadian rhythms and cardiovascular risk factors such as hypertension, obesity, and dyslipidemia. These factors are related to the Metabolic Syndrome (MS), a clustering of metabolic risk factors that increases the risk of several cardiovascular and metabolic diseases. This cross-sectional analysis aimed to explore the RAR characteristics by actigraphy in subjects with MS, particularly in relation to sex and MS parameters, using parametric and non-parametric analyses. Distinguishing the characteristics of RAR based on sex could prove useful as a tool to improve the daily level of activity and set up customized activity programs based on each person's circadian activity profile. This study showed that female participants exhibited higher values than male participants in the Midline Estimating Statistic of Rhythm (MESOR) (243.3 ± 20.0 vs 197.6 ± 17.9 activity count), Amplitude (184.5 ± 18.5 vs 144.2 ± 17.2 activity count), which measures half of the extent of the rhythmic variation in a cycle, and the most active 10-h period (M10) (379.08 ± 16.43 vs 295.13 ± 12.88 activity count). All these parameters are indicative of a higher daily activity level in women. Female participants also had lower Intradaily Variability (IV) than male participants (0.75 ± 0.03 vs 0.85 ± 0.03 activity count), which indicates a more stable and less fragmented RAR. These preliminary data provide the first experimental evidence of a difference in RAR parameters between male and female people with MS.

Copyright © 2021 Mulè, Bruno, Pasanisi, Galasso, Castelli, Caumo, Esposito, Roveda and Montaruli.

Keywords: actigraphy; activity level; chronobiology; circadian rhythms; gender differences; intradaily variability; metabolic syndrome; rest-activity circadian rhythm

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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