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Matsuda K, Kobayakawa T, Kariya R, et al. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Front Microbiol. 2021;12:636276doi: 10.3389/fmicb.2021.636276.
Matsuda, K., Kobayakawa, T., Kariya, R., Tsuchiya, K., Ryu, S., Tsuji, K., Ishii, T., Gatanaga, H., Yoshimura, K., Okada, S., Hamada, A., Mitsuya, H., Tamamura, H., & Maeda, K. (2021). A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Frontiers in microbiology, 12636276. https://doi.org/10.3389/fmicb.2021.636276
Matsuda, Kouki, et al. "A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators." Frontiers in microbiology vol. 12 (2021): 636276. doi: https://doi.org/10.3389/fmicb.2021.636276
Matsuda K, Kobayakawa T, Kariya R, Tsuchiya K, Ryu S, Tsuji K, Ishii T, Gatanaga H, Yoshimura K, Okada S, Hamada A, Mitsuya H, Tamamura H, Maeda K. A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators. Front Microbiol. 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021. PMID: 33815322; PMCID: PMC8010149.
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Front Microbiol. 2021 Mar 17;12:636276. doi: 10.3389/fmicb.2021.636276. eCollection 2021.

A Therapeutic Strategy to Combat HIV-1 Latently Infected Cells With a Combination of Latency-Reversing Agents Containing DAG-Lactone PKC Activators.

Frontiers in microbiology

Kouki Matsuda, Takuya Kobayakawa, Ryusho Kariya, Kiyoto Tsuchiya, Shoraku Ryu, Kohei Tsuji, Takahiro Ishii, Hiroyuki Gatanaga, Kazuhisa Yoshimura, Seiji Okada, Akinobu Hamada, Hiroaki Mitsuya, Hirokazu Tamamura, Kenji Maeda

Affiliations

  1. National Center for Global Health and Medicine Research Institute, Tokyo, Japan.
  2. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Bunky?, Japan.
  3. Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection, Kumamoto University, Kumamoto, Japan.
  4. AIDS Clinical Center, National Center for Global Health and Medicine, Shinjuku, Japan.
  5. Division of Molecular Pharmacology, National Cancer Center Research Institute, Tokyo, Japan.
  6. AIDS Research Centre, National Institute of Infectious Diseases, Tokyo, Japan.
  7. Tokyo Metropolitan Institute of Public Health, Tokyo, Japan.
  8. HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.

PMID: 33815322 PMCID: PMC8010149 DOI: 10.3389/fmicb.2021.636276

Abstract

Advances in antiviral therapy have dramatically improved the therapeutic effects on HIV type 1 (HIV-1) infection. However, even with potent combined antiretroviral therapy, HIV-1 latently infected cells cannot be fully eradicated. Latency-reversing agents (LRAs) are considered a potential tool for eliminating such cells; however, recent

Copyright © 2021 Matsuda, Kobayakawa, Kariya, Tsuchiya, Ryu, Tsuji, Ishii, Gatanaga, Yoshimura, Okada, Hamada, Mitsuya, Tamamura and Maeda.

Keywords: HIV-1; HIV-1 latently infected cells; HIV-1 reservoirs; diacylglycerol-lactone; protein kinase C activator

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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