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Gastaca M, Ruiz P, Bustamante J, et al. Early tacrolimus exposure does not impact long-term outcomes after liver transplantation. World J Hepatol. 2021;13(3):362-374doi: 10.4254/wjh.v13.i3.362.
Gastaca, M., Ruiz, P., Bustamante, J., Martinez-Indart, L., Ventoso, A., Fernandez, J. R., Palomares, I., Prieto, M., Testillano, M., Salvador, P., Senosiain, M., Suárez, M. J., & Valdivieso, A. (2021). Early tacrolimus exposure does not impact long-term outcomes after liver transplantation. World journal of hepatology, 13(3), 362-374. https://doi.org/10.4254/wjh.v13.i3.362
Gastaca, Mikel, et al. "Early tacrolimus exposure does not impact long-term outcomes after liver transplantation." World journal of hepatology vol. 13,3 (2021): 362-374. doi: https://doi.org/10.4254/wjh.v13.i3.362
Gastaca M, Ruiz P, Bustamante J, Martinez-Indart L, Ventoso A, Fernandez JR, Palomares I, Prieto M, Testillano M, Salvador P, Senosiain M, Suárez MJ, Valdivieso A. Early tacrolimus exposure does not impact long-term outcomes after liver transplantation. World J Hepatol. 2021 Mar 27;13(3):362-374. doi: 10.4254/wjh.v13.i3.362. PMID: 33815678; PMCID: PMC8006083.
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World J Hepatol. 2021 Mar 27;13(3):362-374. doi: 10.4254/wjh.v13.i3.362.

Early tacrolimus exposure does not impact long-term outcomes after liver transplantation.

World journal of hepatology

Mikel Gastaca, Patricia Ruiz, Javier Bustamante, Lorea Martinez-Indart, Alberto Ventoso, José Ramón Fernandez, Ibone Palomares, Mikel Prieto, Milagros Testillano, Patricia Salvador, Maria Senosiain, Maria Jesus Suárez, Andres Valdivieso

Affiliations

  1. Department of HPB Surgery and Liver Transplantation Unit, Hospital Universitario Cruces, Bilbao 48903, Spain. [email protected].
  2. Department of HPB Surgery and Liver Transplantation Unit, Hospital Universitario Cruces, Bilbao 48903, Spain.
  3. Department of Hepatology Unit, Hospital Universitario Cruces, Bilbao 48903, Spain.
  4. Department of Bioinformatics and Statistics Platform, Biocruces Bizkaia Health Research Institute, Hospital Universitario Cruces, Bilbao 48903, Spain.

PMID: 33815678 PMCID: PMC8006083 DOI: 10.4254/wjh.v13.i3.362

Abstract

BACKGROUND: Tacrolimus trough levels (TTL) during the first weeks after liver transplantation (LT) have been related with long-term renal function and hepatocellular carcinoma recurrence. Nevertheless, the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate.

AIM: To evaluate the effect of TTL during the first month on the long-term outcomes after LT.

METHODS: One hundred fifty-five LT recipients treated

RESULTS: Mean levels within the first month post-transplant were 7.4 ± 1.7 and 12.6 ± 2.2 ng/mL in the ≤ 10 and > 10 groups, respectively. Donor age was higher in the high TTL group 62.9 ± 16.8 years

CONCLUSION: Differences in tacrolimus levels restricted to the first month after transplant did not result in significant differences in long-term outcomes of LT recipients.

©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: Liver transplantation; Once-daily tacrolimus; Outcomes; Prolonged released tacrolimus; Renal function; Survival; Tacrolimus levels

Conflict of interest statement

Conflict-of-interest statement: MG is a member of advisory boards and has received honoraria from Astellas, Novartis and Chiesi. JB has received honoraria from Astellas and Novartis. AV has received h

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