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Perrone-Capano C, Volpicelli F, Penna E, et al. Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology. Prog Neurobiol. 2021;202:102051doi: 10.1016/j.pneurobio.2021.102051.
Perrone-Capano, C., Volpicelli, F., Penna, E., Chun, J. T., & Crispino, M. (2021). Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology. Progress in neurobiology, 202102051. https://doi.org/10.1016/j.pneurobio.2021.102051
Perrone-Capano, Carla, et al. "Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology." Progress in neurobiology vol. 202 (2021): 102051. doi: https://doi.org/10.1016/j.pneurobio.2021.102051
Perrone-Capano C, Volpicelli F, Penna E, Chun JT, Crispino M. Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology. Prog Neurobiol. 2021 Jul;202:102051. doi: 10.1016/j.pneurobio.2021.102051. Epub 2021 Apr 09. PMID: 33845165.
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Prog Neurobiol. 2021 Jul;202:102051. doi: 10.1016/j.pneurobio.2021.102051. Epub 2021 Apr 09.

Presynaptic protein synthesis and brain plasticity: From physiology to neuropathology.

Progress in neurobiology

Carla Perrone-Capano, Floriana Volpicelli, Eduardo Penna, Jong Tai Chun, Marianna Crispino

Affiliations

  1. Department of Pharmacy, University of Naples Federico II, Naples, Italy; Institute of Genetics and Biophysics "Adriano Buzzati Traverso", CNR, Naples, Italy. Electronic address: [email protected].
  2. Department of Pharmacy, University of Naples Federico II, Naples, Italy. Electronic address: [email protected].
  3. Department of Biology, University of Naples Federico II, Naples, Italy. Electronic address: [email protected].
  4. Department of Biology and Evolution of Marine Organisms, Stazione Zoologica Anton Dohrn, Naples, Italy. Electronic address: [email protected].
  5. Department of Biology, University of Naples Federico II, Naples, Italy. Electronic address: [email protected].

PMID: 33845165 DOI: 10.1016/j.pneurobio.2021.102051

Abstract

To form and maintain extremely intricate and functional neural circuitry, mammalian neurons are typically endowed with highly arborized dendrites and a long axon. The synapses that link neurons to neurons or to other cells are numerous and often too remote for the cell body to make and deliver new proteins to the right place in time. Moreover, synapses undergo continuous activity-dependent changes in their number and strength, establishing the basis of neural plasticity. The innate dilemma is then how a highly complex neuron provides new proteins for its cytoplasmic periphery and individual synapses to support synaptic plasticity. Here, we review a growing body of evidence that local protein synthesis in discrete sites of the axon and presynaptic terminals plays crucial roles in synaptic plasticity, and that deregulation of this local translation system is implicated in various pathologies of the nervous system.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Alzheimer’s disease; Fragile X syndrome; Neurodegenerative diseases; Presynaptic protein synthesis; Psychiatric disorders; Synaptic plasticity

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