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Moratilla A, Sainz de la Maza D, Cadenas Martin M, et al. Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation. Am J Stem Cells. 2021;10(1):1-17
Moratilla, A., Sainz de la Maza, D., Cadenas Martin, M., López-Iglesias, P., González-Peramato, P., & De Miguel, M. P. (2021). Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation. American journal of stem cells, 10(1), 1-17.
Moratilla, Adrian, et al. "Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation." American journal of stem cells vol. 10,1 (2021): 1-17.
Moratilla A, Sainz de la Maza D, Cadenas Martin M, López-Iglesias P, González-Peramato P, De Miguel MP. Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation. Am J Stem Cells. 2021 Feb 15;10(1):1-17. eCollection 2021. PMID: 33815934; PMCID: PMC8012778.
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Am J Stem Cells. 2021 Feb 15;10(1):1-17. eCollection 2021.

Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation.

American journal of stem cells

Adrian Moratilla, Diego Sainz de la Maza, Marta Cadenas Martin, Pilar López-Iglesias, Pilar González-Peramato, Maria P De Miguel

Affiliations

  1. Cell Engineering Laboratory, La Paz University Hospital Health Research Institute IDiPAZ, Madrid, Spain.

PMID: 33815934 PMCID: PMC8012778

Abstract

Historically, primordial germ cells (PGCs) have been a good model to study pluripotency. Despite their low numbers and limited accessibility in the mouse embryo, they can be easily and rapidly reprogrammed at high efficiency with external physicochemical factors and do not require transcription factor transfection. Employing this model to deepen our understanding of cell reprogramming, we specifically aimed to determine the relevance of Ca

AJSC Copyright © 2021.

Keywords: Cellular reprograming; HIF; PKC; calcium signaling; histone acetylation; pluripotency; primordial germ cells

Conflict of interest statement

None.

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