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Sajid MI, Moazzam M, Stueber R, et al. Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool. Peptides. 2021;141:170542doi: 10.1016/j.peptides.2021.170542.
Sajid, M. I., Moazzam, M., Stueber, R., Park, S. E., Cho, Y., Malik, N. U. A., & Tiwari, R. K. (2021). Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool. Peptides, 141170542. https://doi.org/10.1016/j.peptides.2021.170542
Sajid, Muhammad Imran, et al. "Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool." Peptides vol. 141 (2021): 170542. doi: https://doi.org/10.1016/j.peptides.2021.170542
Sajid MI, Moazzam M, Stueber R, Park SE, Cho Y, Malik NUA, Tiwari RK. Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool. Peptides. 2021 Jul;141:170542. doi: 10.1016/j.peptides.2021.170542. Epub 2021 Mar 29. PMID: 33794283.
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Peptides. 2021 Jul;141:170542. doi: 10.1016/j.peptides.2021.170542. Epub 2021 Mar 29.

Applications of amphipathic and cationic cyclic cell-penetrating peptides: Significant therapeutic delivery tool.

Peptides

Muhammad Imran Sajid, Muhammad Moazzam, Ryan Stueber, Shang Eun Park, Yeseom Cho, Noor Ul Ain Malik, Rakesh K Tiwari

Affiliations

  1. Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, USA; Faculty of Pharmacy, University of Central Punjab, Lahore, 54000, Pakistan.
  2. Faculty of Pharmacy, University of Central Punjab, Lahore, 54000, Pakistan.
  3. Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, USA.
  4. Center for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, Irvine, CA, 92618, USA. Electronic address: [email protected].

PMID: 33794283 DOI: 10.1016/j.peptides.2021.170542

Abstract

A new class of peptides, cyclic cell-penetrating peptides (CPPs), has great potential for delivering a vast variety of therapeutics intracellularly for treating diverse ailments. CPPs have been used previously; however, their further use is limited due to instability, toxicity, endosomal degradation, and insufficient cellular penetration. Cyclic CPPs are being investigated in delivering therapeutics to treat various ailments, including multi-drug resistant microbial infections, HIV, and cancer. They can act as a carrier for a variety of cargos and target intracellularly. Approximately 40 cyclic peptides-based therapeutics are available in the market, and annually one cyclic peptide-based drug enters the market. Numerous research and review articles have been published in the last decade about linear and cyclic peptides separately. This review is the first to provide a comprehensive deliberation about cationic and amphipathic cyclic CPPs. Herein, we highlights their structures, significant advantages, translocation mechanisms, and delivery application in the area of biomedical sciences.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Amphipathic; Biomedical application; Cationic; Cell-penetrating peptides; Cyclic cell-penetrating peptides; Stability; Translocation mechanism

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