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Vanasco V, Ropolo A, Grasso D, et al. Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis. Front Cell Dev Biol. 2021;9:640094doi: 10.3389/fcell.2021.640094.
Vanasco, V., Ropolo, A., Grasso, D., Ojeda, D. S., García, M. N., Vico, T. A., Orquera, T., Quarleri, J., Alvarez, S., & Vaccaro, M. I. (2021). Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis. Frontiers in cell and developmental biology, 9640094. https://doi.org/10.3389/fcell.2021.640094
Vanasco, Virginia, et al. "Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis." Frontiers in cell and developmental biology vol. 9 (2021): 640094. doi: https://doi.org/10.3389/fcell.2021.640094
Vanasco V, Ropolo A, Grasso D, Ojeda DS, García MN, Vico TA, Orquera T, Quarleri J, Alvarez S, Vaccaro MI. Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis. Front Cell Dev Biol. 2021 Mar 18;9:640094. doi: 10.3389/fcell.2021.640094. eCollection 2021. PMID: 33816487; PMCID: PMC8012556.
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Front Cell Dev Biol. 2021 Mar 18;9:640094. doi: 10.3389/fcell.2021.640094. eCollection 2021.

Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis.

Frontiers in cell and developmental biology

Virginia Vanasco, Alejandro Ropolo, Daniel Grasso, Diego S Ojeda, María Noé García, Tamara A Vico, Tamara Orquera, Jorge Quarleri, Silvia Alvarez, María I Vaccaro

Affiliations

  1. Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Bioquímica y Medicina Molecular (IBIMOL), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.
  2. Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Instituto de Investigaciones Biomédicas en Retrovirus y SIDA (INBIRS), Facultad de Medicina, Buenos Aires, Argentina.

PMID: 33816487 PMCID: PMC8012556 DOI: 10.3389/fcell.2021.640094

Abstract

Mitophagy and zymophagy are selective autophagy pathways early induced in acute pancreatitis that may explain the mild, auto limited, and more frequent clinical presentation of this disease. Adequate mitochondrial bioenergetics is necessary for cellular restoration mechanisms that are triggered during the mild disease. However, mitochondria and zymogen contents are direct targets of damage in acute pancreatitis. Cellular survival depends on the recovering possibility of mitochondrial function and efficient clearance of damaged mitochondria. This work aimed to analyze mitochondrial dynamics and function during selective autophagy in pancreatic acinar cells during mild experimental pancreatitis in rats. Also, using a cell model under the hyperstimulation of the G-coupled receptor for CCK (CCK-R), we aimed to investigate the mechanisms involved in these processes in the context of zymophagy. We found that during acute pancreatitis, mitochondrial O

Copyright © 2021 Vanasco, Ropolo, Grasso, Ojeda, García, Vico, Orquera, Quarleri, Alvarez and Vaccaro.

Keywords: DRP1; Parkin1; VMP1; autophagy; mitochondrial dynamics; mitochondrial function; mitophagy; pancreatitis

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

  1. Front Immunol. 2018 Nov 20;9:2633 - PubMed
  2. Free Radic Biol Med. 2016 Nov;100:210-222 - PubMed
  3. Gastroenterology. 2011 Jun;140(7):2116-25 - PubMed
  4. J Biol Chem. 2007 Dec 21;282(51):37124-33 - PubMed
  5. Cell Metab. 2015 Aug 4;22(2):207-18 - PubMed
  6. J Bioenerg Biomembr. 2012 Apr;44(2):243-52 - PubMed
  7. Methods Mol Biol. 2019;1880:541-554 - PubMed
  8. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15927-32 - PubMed
  9. Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6400-5 - PubMed
  10. PLoS Biol. 2010 Jan 26;8(1):e1000298 - PubMed
  11. Gut. 2016 Aug;65(8):1333-46 - PubMed
  12. Methods Cell Biol. 2007;80:155-71 - PubMed
  13. Biochem Biophys Res Commun. 2002 Jan 18;290(2):641-9 - PubMed
  14. Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):E6166-74 - PubMed
  15. Cell Mol Neurobiol. 2018 Jul;38(5):995-1007 - PubMed
  16. Gastroenterology. 2018 Feb;154(3):689-703 - PubMed
  17. Autophagy. 2008 Apr;4(3):388-90 - PubMed
  18. Free Radic Biol Med. 2014 Dec;77:1-9 - PubMed
  19. Neurology. 2017 Jan 10;88(2):131-142 - PubMed
  20. J Biol Chem. 2011 Mar 11;286(10):8308-8324 - PubMed
  21. Mediators Inflamm. 2015;2015:901780 - PubMed
  22. Acta Physiol (Oxf). 2013 Feb;207(2):226-35 - PubMed
  23. Gastroenterology. 2015 Mar;148(3):626-638.e17 - PubMed
  24. Nat Cell Biol. 2011 May;13(5):589-98 - PubMed
  25. Cell Metab. 2013 Apr 2;17(4):491-506 - PubMed
  26. J Cell Sci. 2012 Feb 15;125(Pt 4):795-9 - PubMed
  27. Mol Biol Cell. 2001 Aug;12(8):2245-56 - PubMed
  28. J Cell Sci. 2001 Mar;114(Pt 5):867-74 - PubMed
  29. Int J Cell Biol. 2012;2012:396705 - PubMed
  30. J Cell Biol. 2008 Dec 1;183(5):795-803 - PubMed
  31. Nat Cell Biol. 2010 Feb;12(2):119-31 - PubMed
  32. Front Endocrinol (Lausanne). 2020 Jun 23;11:411 - PubMed
  33. Adv Exp Med Biol. 2012;748:13-40 - PubMed
  34. J Cell Biol. 1973 Oct;59(1):222-7 - PubMed
  35. Basic Res Cardiol. 2019 Aug 19;114(5):38 - PubMed
  36. Biochem J. 1980 Apr 15;188(1):31-7 - PubMed
  37. PLoS Pathog. 2013;9(12):e1003722 - PubMed
  38. Antioxidants (Basel). 2018 Jan 16;7(1): - PubMed
  39. EMBO J. 2011 Jun 1;30(11):2101-14 - PubMed
  40. Microsc Res Tech. 1994 Feb 15;27(3):198-219 - PubMed
  41. Gastroenterology. 2013 Feb;144(2):437-446.e6 - PubMed
  42. Cell Calcium. 2008 Jul;44(1):14-23 - PubMed
  43. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4350-4 - PubMed
  44. Free Radic Biol Med. 2019 Nov 1;143:70-83 - PubMed
  45. Antioxid Redox Signal. 2011 Nov 15;15(10):2683-98 - PubMed
  46. Curr Opin Gastroenterol. 2008 Sep;24(5):573-9 - PubMed
  47. Lancet Gastroenterol Hepatol. 2016 Sep;1(1):45-55 - PubMed
  48. Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):378-83 - PubMed

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