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Hossain MI, Thomas AG, Mahdi F, et al. An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity. RSC Adv. 2021;11(13):7115-7128doi: 10.1039/d0ra08249j.
Hossain, M. I., Thomas, A. G., Mahdi, F., Adam, A. T., Akins, N. S., Woodard, M. M., Paris, J. J., Slusher, B. S., & Le, H. V. (2021). An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity. RSC advances, 11(13), 7115-7128. https://doi.org/10.1039/d0ra08249j
Hossain, Md Imran, et al. "An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity." RSC advances vol. 11,13 (2021): 7115-7128. doi: https://doi.org/10.1039/d0ra08249j
Hossain MI, Thomas AG, Mahdi F, Adam AT, Akins NS, Woodard MM, Paris JJ, Slusher BS, Le HV. An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity. RSC Adv. 2021 Feb 24;11(13):7115-7128. doi: 10.1039/d0ra08249j. Epub 2021 Feb 10. PMID: 33777357; PMCID: PMC7968037.
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RSC Adv. 2021 Feb 24;11(13):7115-7128. doi: 10.1039/d0ra08249j. Epub 2021 Feb 10.

An efficient synthetic route to l-γ-methyleneglutamine and its amide derivatives, and their selective anticancer activity.

RSC advances

Md Imran Hossain, Ajit G Thomas, Fakhri Mahdi, Amna T Adam, Nicholas S Akins, Morgan M Woodard, Jason J Paris, Barbara S Slusher, Hoang V Le

Affiliations

  1. Department of BioMolecular Sciences, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Mississippi 38677, USA. Email: [email protected].
  2. Johns Hopkins Drug Discovery, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

PMID: 33777357 PMCID: PMC7968037 DOI: 10.1039/d0ra08249j

Abstract

In cancer cells, glutaminolysis is the primary source of biosynthetic precursors, fueling the TCA cycle with glutamine-derived α-ketoglutarate. The enhanced production of α-ketoglutarate is critical to cancer cells as it provides carbons for the TCA cycle to produce glutathione, fatty acids, and nucleotides, and contributes nitrogens to produce hexosamines, nucleotides, and many nonessential amino acids. Efforts to inhibit glutamine metabolism in cancer using amino acid analogs have been extensive. l-γ-Methyleneglutamine was shown to be of considerable biochemical importance, playing a major role in nitrogen transport in

This journal is © The Royal Society of Chemistry 2021.

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