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Iida N, Takemura K, Ito M, et al. Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin. Int J Surg Pathol. 2021;29(8):887-891doi: 10.1177/10668969211008980.
Iida, N., Takemura, K., Ito, M., Funata, N., Yonese, I., Suzuki, H., Tsuzuki, T., & Koga, F. (2021). Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin. International journal of surgical pathology, 29(8), 887-891. https://doi.org/10.1177/10668969211008980
Iida, Noriyuki, et al. "Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin." International journal of surgical pathology vol. 29,8 (2021): 887-891. doi: https://doi.org/10.1177/10668969211008980
Iida N, Takemura K, Ito M, Funata N, Yonese I, Suzuki H, Tsuzuki T, Koga F. Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin. Int J Surg Pathol. 2021 Dec;29(8):887-891. doi: 10.1177/10668969211008980. Epub 2021 Apr 13. PMID: 33847540.
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Int J Surg Pathol. 2021 Dec;29(8):887-891. doi: 10.1177/10668969211008980. Epub 2021 Apr 13.

Primary Testicular Neuroendocrine Tumor Coexisting With Seminoma Sharing Germ Cell Origin.

International journal of surgical pathology

Noriyuki Iida, Kosuke Takemura, Masaya Ito, Nobuaki Funata, Ichiro Yonese, Hiroaki Suzuki, Toyonori Tsuzuki, Fumitaka Koga

Affiliations

  1. 118084Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo, Japan.
  2. 12703Aichi Medical University Hospital, Aichi, Japan.

PMID: 33847540 DOI: 10.1177/10668969211008980

Abstract

A 40-year-old, male, Japanese patient presented with the complaint of painless, right testicular swelling. Tumor markers for testicular cancer were normal. He underwent radical orchiectomy with the clinical diagnosis of stage I seminoma. Pathological examination revealed seminoma and coexisting neuroendocrine tumor (NET). Germ cell neoplasia in situ (GCNIS) was present in the vicinity of seminoma, but there was no continuity between NET and seminoma. Tumor cells of both lesions displayed amplification of 12p and isochromosome 12p on fluorescence in situ hybridization, suggesting that both tumors originated from GCNIS. The present report is the first to describe a case of primary testicular NET coexisting with seminoma in an ipsilateral testis.

Keywords: chromosome 12; germ cell neoplasia in situ; neuroendocrine tumor; seminoma; testis

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