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Al-Khan AA, Al Balushi NR, Richardson SJ, et al. Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma. Front Vet Sci. 2021;8:637614doi: 10.3389/fvets.2021.637614.
Al-Khan, A. A., Al Balushi, N. R., Richardson, S. J., & Danks, J. A. (2021). Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma. Frontiers in veterinary science, 8637614. https://doi.org/10.3389/fvets.2021.637614
Al-Khan, Awf A, et al. "Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma." Frontiers in veterinary science vol. 8 (2021): 637614. doi: https://doi.org/10.3389/fvets.2021.637614
Al-Khan AA, Al Balushi NR, Richardson SJ, Danks JA. Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma. Front Vet Sci. 2021 Mar 16;8:637614. doi: 10.3389/fvets.2021.637614. eCollection 2021. PMID: 33796580; PMCID: PMC8008073.
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Front Vet Sci. 2021 Mar 16;8:637614. doi: 10.3389/fvets.2021.637614. eCollection 2021.

Roles of Parathyroid Hormone-Related Protein (PTHrP) and Its Receptor (PTHR1) in Normal and Tumor Tissues: Focus on Their Roles in Osteosarcoma.

Frontiers in veterinary science

Awf A Al-Khan, Noora R Al Balushi, Samantha J Richardson, Janine A Danks

Affiliations

  1. School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia.
  2. Department of Pathology, Sohar Hospital, Sohar, Oman.
  3. School of Science, RMIT University, Bundoora, VIC, Australia.
  4. The University of Melbourne, Department of Medicine, Austin Health, Heidelberg, VIC, Australia.

PMID: 33796580 PMCID: PMC8008073 DOI: 10.3389/fvets.2021.637614

Abstract

Osteosarcoma (OS) is the most common primary bone tumor and originates from bone forming mesenchymal cells and primarily affects children and adolescents. The 5-year survival rate for OS is 60 to 65%, with little improvement in prognosis during the last four decades. Studies have demonstrated the evolving roles of parathyroid hormone-related protein (PTHrP) and its receptor (PTHR1) in bone formation, bone remodeling, regulation of calcium transport from blood to milk, regulation of maternal calcium transport to the fetus and reabsorption of calcium in kidneys. These two molecules also play critical roles in the development, progression and metastasis of several tumors such as breast cancer, lung carcinoma, chondrosarcoma, squamous cell carcinoma, melanoma and OS. The protein expression of both PTHrP and PTHR1 have been demonstrated in OS, and their functions and proposed signaling pathways have been investigated yet their roles in OS have not been fully elucidated. This review aims to discuss the latest research with PTHrP and PTHR1 in OS tumorigenesis and possible mechanistic pathways. This review is dedicated to Professor Michael Day who died in May 2020 and was a very generous collaborator.

Copyright © 2021 Al-Khan, Al Balushi, Richardson and Danks.

Keywords: canine; osteosarcoma; parathyroid hormone; parathyroid hormone related protein; prognostic factor

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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