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Rezende CP, Martins Oliveira Brito PK, Pessoni AM, et al. Altered expression of genes related to innate antifungal immunity in the absence of galectin-3. Virulence. 2021;12(1):981-988doi: 10.1080/21505594.2021.1903212.
Rezende, C. P., Martins Oliveira Brito, P. K., Pessoni, A. M., Da Silva, T. A., Goldman, G. H., & Almeida, F. (2021). Altered expression of genes related to innate antifungal immunity in the absence of galectin-3. Virulence, 12(1), 981-988. https://doi.org/10.1080/21505594.2021.1903212
Rezende, Caroline Patini, et al. "Altered expression of genes related to innate antifungal immunity in the absence of galectin-3." Virulence vol. 12,1 (2021): 981-988. doi: https://doi.org/10.1080/21505594.2021.1903212
Rezende CP, Martins Oliveira Brito PK, Pessoni AM, Da Silva TA, Goldman GH, Almeida F. Altered expression of genes related to innate antifungal immunity in the absence of galectin-3. Virulence. 2021 Dec;12(1):981-988. doi: 10.1080/21505594.2021.1903212. PMID: 33779504; PMCID: PMC8009118.
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Virulence. 2021 Dec;12(1):981-988. doi: 10.1080/21505594.2021.1903212.

Altered expression of genes related to innate antifungal immunity in the absence of galectin-3.

Virulence

Caroline Patini Rezende, Patricia Kellen Martins Oliveira Brito, Andre Moreira Pessoni, Thiago Aparecido Da Silva, Gustavo H Goldman, Fausto Almeida

Affiliations

  1. Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
  2. Department of Cellular and Molecular Biology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
  3. Departamento De Ciencias Farmaceuticas, Faculdade De Ciencias Farmaceuticas De Ribeirao Preto, Universidade De Sao Paulo, Ribeirao Preto, SP, Brazil.

PMID: 33779504 PMCID: PMC8009118 DOI: 10.1080/21505594.2021.1903212

Abstract

Galectin-3 (Gal-3) is the most studied member of the animal galectin family, which comprises β-galactoside-binding lectins and participates in several cellular events. Its expression in cells involved in innate and adaptive immunity is related to anti- and proinflammatory functions, signaling an important role in inflammatory, infectious, and tumorigenesis processes. Mice deficient in Gal-3 exhibit important phenotypes, but it is unclear whether these phenotypes reflect an impairment of the functions of this protein. Gal-3 plays an important role in modulating the immune response to different pathogenic microorganisms. However, the role of Gal-3 in immunity to infection is still poorly understood. Therefore, we investigated the effects of Gal-3 deletion on the expression of genes involved in the innate immune response in the lungs, spleens, and brains of Gal-3 KO mice. Gene profiling expression analysis suggested that Gal-3 deletion resulted in differentially modulated expression of the genes encoding beta-glucan, mannose and chitin-responsive pattern recognition receptors, signal transduction, inflammation, and phagocytosis. Our data thus suggest the importance of Gal-3 expression in the host innate immune system.

Keywords: Galectin-3; antifungal immunity; gene expression; gene knockout; innate immune response

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