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Otolaryngol Head Neck Surg. 2021 Apr 13;1945998211004578. doi: 10.1177/01945998211004578. Epub 2021 Apr 13.

Laryngeal Chondrosarcoma Characteristics and Survival Analysis in the National Cancer Database.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery

Vidit M Talati, Matthew J Urban, Tirth R Patel, Christopher Wojcik, Bobby A Tajudeen, Kerstin Stenson, Mihir K Bhayani, Samer Al-Khudari, Inna A Husain

Affiliations

  1. Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, Illinois, USA.
  2. Chicago College of Osteopathic Medicine, Chicago, Illinois, USA.

PMID: 33848444 DOI: 10.1177/01945998211004578

Abstract

OBJECTIVE: To highlight various patient, tumor, diagnostic, and treatment characteristics of laryngeal chondrosarcoma (LC) as well as elucidate factors that may independently affect overall survival (OS) for LCs.

STUDY DESIGN: Retrospective cohort study.

SETTING: National Cancer Database (NCDB).

METHODS: All LC cases from 2004 to 2016 were extracted from the NCDB. Several demographic, diagnostic, and treatment variables were compared between LC subgroups using χ

RESULTS: There were 348 LCs included in the main cohort. LCs were predominantly non-Hispanic white males with similar rates of private and government insurance (49.4% vs 45.4%). Most LCs (81.6%) underwent primary surgery, particularly partial and total laryngectomy. The 1-, 5-, and 10-year survivals for LC were 95.7%, 88.2%, and 66.3%, respectively. On multivariate analysis, lack of insurance (

CONCLUSION: This is the first multivariate survival analysis and largest single cohort study of LCs in the literature. Overall, LCs enjoy an excellent prognosis, with insurance status, grade, and histology as the main predictors of survival.

Keywords: National Cancer Database; chondrosarcoma of the larynx; demographic; laryngeal chondrosarcoma; malignancy; survival analysis

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