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Clin J Am Soc Nephrol. 2021 Mar 29; doi: 10.2215/CJN.14570920. Epub 2021 Mar 29.

[No title available]

Clinical journal of the American Society of Nephrology : CJASN

David Al-Adra, Talal Al-Qaoud, Kevin Fowler, Germaine Wong

Affiliations

  1. Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
  2. The Voice of the Patient, Inc., Columbia, Missouri.
  3. Sydney School of Public Health, University of Sydney, Sydney, New South Wales, Australia [email protected].
  4. Centre for Kidney Research, Kids Research Institute, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.
  5. Centre for Transplant and Renal Research, Westmead Hospital, Westmead, New South Wales, Australia.

PMID: 33782034 DOI: 10.2215/CJN.14570920

Abstract

Cancer is an important outcome after kidney transplantation because it is the second leading cause of death in most Western countries. The excess risk of cancer after transplantation is approximately two to three times higher than the age- and sex-matched general population, driven largely by viral- and immune-related cancers. Once cancer develops, outcomes are generally poor, particularly for those with melanoma, renal cell carcinoma, and post-transplant lymphoproliferative disease. More importantly, effective screening and treatment strategies are limited in this high-risk population. In this review, we begin with a patient's journey that maps the experience of living with a kidney transplant and understand the patient's knowledge, education, and experience of cancer in the context of transplantation. The epidemiology and burden of cancer in recipients of kidney transplants, along with the up-to-date screening and treatment strategies, are discussed. We also focus on the current understanding of optimal care for recipients of kidney transplants who are living with cancer from the patients' perspectives.

Copyright © 2022 by the American Society of Nephrology.

Keywords: Kidney Transplantation Series; cancer; kidney transplantation

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