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van der Meer PB, Koekkoek JAF, van den Bent MJ, et al. Effect of antiepileptic drugs in glioma patients on self-reported depression, anxiety, and cognitive complaints. J Neurooncol. 2021;153(1):89-98doi: 10.1007/s11060-021-03747-1.
van der Meer, P. B., Koekkoek, J. A. F., van den Bent, M. J., Dirven, L., & Taphoorn, M. J. B. (2021). Effect of antiepileptic drugs in glioma patients on self-reported depression, anxiety, and cognitive complaints. Journal of neuro-oncology, 153(1), 89-98. https://doi.org/10.1007/s11060-021-03747-1
van der Meer, Pim B, et al. "Effect of antiepileptic drugs in glioma patients on self-reported depression, anxiety, and cognitive complaints." Journal of neuro-oncology vol. 153,1 (2021): 89-98. doi: https://doi.org/10.1007/s11060-021-03747-1
van der Meer PB, Koekkoek JAF, van den Bent MJ, Dirven L, Taphoorn MJB. Effect of antiepileptic drugs in glioma patients on self-reported depression, anxiety, and cognitive complaints. J Neurooncol. 2021 May;153(1):89-98. doi: 10.1007/s11060-021-03747-1. Epub 2021 Apr 06. PMID: 33822293; PMCID: PMC8131297.
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J Neurooncol. 2021 May;153(1):89-98. doi: 10.1007/s11060-021-03747-1. Epub 2021 Apr 06.

Effect of antiepileptic drugs in glioma patients on self-reported depression, anxiety, and cognitive complaints.

Journal of neuro-oncology

Pim B van der Meer, Johan A F Koekkoek, Martin J van den Bent, Linda Dirven, Martin J B Taphoorn

Affiliations

  1. Department of Neurology, Leiden University Medical Center, PO BOX 9600, Leiden, 2300 RC, The Netherlands. [email protected].
  2. Department of Neurology, Leiden University Medical Center, PO BOX 9600, Leiden, 2300 RC, The Netherlands.
  3. Department of Neurology, Haaglanden Medical Center, The Hague, The Netherlands.
  4. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.

PMID: 33822293 PMCID: PMC8131297 DOI: 10.1007/s11060-021-03747-1

Abstract

INTRODUCTION: AEDs have been associated with depression, anxiety, and cognitive impairment, all frequent complications of glioma and its subsequent treatment, with considerable morbidity and an adverse effect on health-related quality of life. This study aimed to determine the independent association between AED use and self-reported depression, anxiety, and subjective cognitive impairment in glioma patients.

METHODS: In this multicenter cross-sectional study, depression and anxiety were assessed with the HADS and subjective cognitive impairment was assessed with the MOS-CFS. Univariable logistic regression analyses were performed on all potential confounding predictor variables. Potential confounders were included in the multivariable analyses if p-value < 0.1, to evaluate whether use of AEDs was independently related to depression, anxiety, and/or subjective cognitive impairment.

RESULTS: A total of 272 patients were included. Prevalence of depression differed significantly between patients not using (10%) and using AEDs (21%, unadjusted Odds Ratio [uOR] = 2.29 [95%CI 1.05-4.97], p = 0.037), but after correction for confounders the statistical significant difference was no longer apparent (adjusted Odds Ratio [aOR] = 1.94 [95%CI 0.83-4.50], p = 0.125). Prevalences of anxiety (aOR = 1.17 [95%CI 0.59-2.29], p = 0.659) and subjective cognitive impairment (aOR = 0.83 [95%CI 0.34-2.04], p = 0.684) did not differ significantly before or after adjustment of confounders between patients not using (19% and 16%, respectively) and using AEDs (26% and 21%, respectively).

CONCLUSIONS: Our results indicate AED use was not independently associated with concurrent depression, anxiety, or subjective cognitive impairment in glioma patients. Alternative factors seem to have a greater contribution to the risk of developing neuropsychiatric symptoms in glioma patients.

Keywords: Anticonvulsants; Anxiety; Cognition; Depression; Glioma; Seizures

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