Display options
Cite
Yi M, Negishi M, Lee SJ. Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives. J Pers Med. 2021;11(3)doi: 10.3390/jpm11030194.
Yi, M., Negishi, M., & Lee, S. J. (2021). Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives. Journal of personalized medicine, 11(3), . https://doi.org/10.3390/jpm11030194
Yi, MyeongJin, et al. "Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives." Journal of personalized medicine vol. 11,3 (2021). doi: https://doi.org/10.3390/jpm11030194
Yi M, Negishi M, Lee SJ. Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives. J Pers Med. 2021 Mar 11;11(3). doi: 10.3390/jpm11030194. PMID: 33799763; PMCID: PMC8001535.
Copy Download .nbib Format: NLM
Share it on

J Pers Med. 2021 Mar 11;11(3). doi: 10.3390/jpm11030194.

Estrogen Sulfotransferase (SULT1E1): Its Molecular Regulation, Polymorphisms, and Clinical Perspectives.

Journal of personalized medicine

MyeongJin Yi, Masahiko Negishi, Su-Jun Lee

Affiliations

  1. Pharmacogenetics Section, Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.
  2. Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Inje University, Bokji-ro 75, Busanjin-gu, Busan 47392, Korea.

PMID: 33799763 PMCID: PMC8001535 DOI: 10.3390/jpm11030194

Abstract

Estrogen sulfotransferase (SULT1E1) is a phase II enzyme that sulfates estrogens to inactivate them and regulate their homeostasis. This enzyme is also involved in the sulfation of thyroid hormones and several marketed medicines. Though the profound action of SULT1E1 in molecular/pathological biology has been extensively studied, its genetic variants and functional studies have been comparatively rarely studied. Genetic variants of this gene are associated with some diseases, especially sex-hormone-related cancers. Comprehending the role and polymorphisms of SULT1E1 is crucial to developing and integrating its clinical relevance; therefore, this study gathered and reviewed various literature studies to outline several aspects of the function, molecular regulation, and polymorphisms of SULT1E1.

Keywords: SULT1E1; breast cancer; endometrial cancer; estrogen; estrogen sulfate; estrogen sulfotransferase; polymorphism; thyroid hormones

References

  1. Calcif Tissue Int. 2006 Sep;79(3):152-9 - PubMed
  2. Int J Cancer. 1997 Mar 17;70(6):639-43 - PubMed
  3. J Urol. 2016 Oct;196(4):1112-6 - PubMed
  4. Mol Hum Reprod. 1999 Nov;5(11):995-1002 - PubMed
  5. Biochem Biophys Res Commun. 2002 Mar 29;292(2):402-8 - PubMed
  6. Eur J Clin Nutr. 2004 Dec;58(12):1635-42 - PubMed
  7. Drug Metab Rev. 2013 Nov;45(4):441-9 - PubMed
  8. Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1090-5 - PubMed
  9. Drug Metab Dispos. 2015 Jun;43(6):843-50 - PubMed
  10. J Endocrinol Invest. 1999 Apr;22(4):257-61 - PubMed
  11. Mol Pharmacol. 1998 Feb;53(2):274-82 - PubMed
  12. Menopause. 2010 Sep-Oct;17(5):1026-34 - PubMed
  13. Nat Struct Biol. 1997 Nov;4(11):904-8 - PubMed
  14. Biomedicines. 2018 Sep 09;6(3): - PubMed
  15. J Pharmacol Exp Ther. 2007 Jan;320(1):307-13 - PubMed
  16. Microbiol Res. 2016 Oct;191:32-7 - PubMed
  17. J Steroid Biochem Mol Biol. 1995 Jun;52(6):529-39 - PubMed
  18. Arch Toxicol. 2018 Jun;92(6):1991-1999 - PubMed
  19. J Clin Endocrinol Metab. 1999 Apr;84(4):1357-64 - PubMed
  20. Thyroid. 1992 Summer;2(2):101-5 - PubMed
  21. PLoS One. 2011;6(6):e21229 - PubMed
  22. J Steroid Biochem Mol Biol. 2001 Apr;77(1):83-6 - PubMed
  23. Drug Metab Dispos. 2012 Jun;40(6):1210-5 - PubMed
  24. FEBS Lett. 2018 Aug;592(16):2760-2768 - PubMed
  25. Anticancer Res. 2003 Nov-Dec;23(6C):4651-5 - PubMed
  26. Mol Med Rep. 2013 Jul;8(1):133-9 - PubMed
  27. Mol Cell Endocrinol. 2013 Apr 30;369(1-2):140-9 - PubMed
  28. Dis Markers. 2000;16(3-4):151-7 - PubMed
  29. Chem Biol Interact. 1998 Feb 20;109(1-3):329-39 - PubMed
  30. Drug Metab Dispos. 1996 Aug;24(8):854-8 - PubMed
  31. Int J Mol Sci. 2019 Mar 15;20(6): - PubMed
  32. Pharmgenomics Pers Med. 2011 Nov 16;4:137-145 - PubMed
  33. J Agric Food Chem. 2020 Nov 25;68(47):13879-13887 - PubMed
  34. Chem Biol Interact. 1994 Jun;92(1-3):273-9 - PubMed
  35. Genomics. 1995 Sep 1;29(1):16-23 - PubMed
  36. Biochem Pharmacol. 2017 Dec 1;145:202-209 - PubMed
  37. J Clin Invest. 1994 May;93(5):2007-13 - PubMed
  38. J Endocrinol. 2008 May;197(2):315-23 - PubMed
  39. Drug Metab Dispos. 2002 Aug;30(8):944-9 - PubMed
  40. J Pharmacol Exp Ther. 1998 Jul;286(1):555-60 - PubMed
  41. Diabetes. 2012 Jun;61(6):1543-51 - PubMed
  42. FASEB J. 1997 Mar;11(4):206-16 - PubMed
  43. J Exp Zool A Comp Exp Biol. 2003 Jul 1;298(1):32-43 - PubMed
  44. Hum Genomics. 2015 Jul 22;9:16 - PubMed
  45. Br J Cancer. 1997;76(3):401-5 - PubMed
  46. J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):383-91 - PubMed
  47. Sci Rep. 2020 Mar 19;10(1):5001 - PubMed
  48. BMJ Open. 2018 Aug 1;8(7):e021805 - PubMed
  49. J Steroid Biochem Mol Biol. 1994 Mar;48(4):369-75 - PubMed
  50. Endocrinology. 1996 Apr;137(4):1395-401 - PubMed
  51. J Biol Chem. 1998 Oct 16;273(42):27325-30 - PubMed
  52. Ann Hum Genet. 2008 Nov;72(Pt 6):821-33 - PubMed
  53. J Clin Endocrinol Metab. 2001 Dec;86(12):5944-55 - PubMed
  54. Nat Commun. 2015 Aug 10;6:7979 - PubMed
  55. Toxicol In Vitro. 2020 Jun;65:104813 - PubMed
  56. Biochem J. 2020 Sep 30;477(18):3583-3598 - PubMed
  57. Endocrinology. 2000 May;141(5):1587-9 - PubMed
  58. J Steroid Biochem. 1975 Nov-Dec;6(11-12):1489-94 - PubMed
  59. J Pharmacol Exp Ther. 1998 Mar;284(3):1197-202 - PubMed
  60. Environ Health Perspect. 2003 Jun;111(7):884-8 - PubMed
  61. FASEB J. 1997 May;11(6):404-18 - PubMed
  62. J Clin Endocrinol Metab. 1996 Apr;81(4):1460-4 - PubMed
  63. Cancer Res. 1996 Apr 1;56(7):1551-5 - PubMed
  64. J Steroid Biochem Mol Biol. 1999 Feb;68(3-4):137-44 - PubMed
  65. Mutat Res. 2001 Oct 1;482(1-2):27-40 - PubMed
  66. J Clin Endocrinol Metab. 1999 Jul;84(7):2577-80 - PubMed
  67. Cancer Res. 2008 Sep 15;68(18):7386-93 - PubMed
  68. J Biol Chem. 2018 Aug 17;293(33):12759-12769 - PubMed
  69. Endocrinology. 2001 Dec;142(12):5342-50 - PubMed
  70. Biochem Pharmacol. 2020 Oct;180:114197 - PubMed
  71. FASEB J. 1997 Jan;11(1):3-14 - PubMed
  72. Biochem Pharmacol. 2000 Dec 1;60(11):1713-6 - PubMed
  73. J Biol Chem. 2002 May 17;277(20):17928-32 - PubMed
  74. Br J Pharmacol. 2003 Aug;139(8):1373-82 - PubMed
  75. Toxicol Sci. 2006 Mar;90(1):5-22 - PubMed
  76. Nutrients. 2016 Mar 15;8(3):167 - PubMed
  77. J Biol Chem. 1995 Aug 11;270(32):18941-7 - PubMed
  78. Ann N Y Acad Sci. 2002 Jun;963:221-8 - PubMed
  79. Mol Endocrinol. 2007 Aug;21(8):1781-90 - PubMed
  80. Biochem Biophys Res Commun. 1994 May 16;200(3):1621-9 - PubMed
  81. J Biol Chem. 1998 May 1;273(18):10888-92 - PubMed
  82. Cancer. 2008 May 1;112(9):1964-73 - PubMed
  83. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13801-6 - PubMed
  84. Drug Metab Dispos. 2004 Nov;32(11):1299-303 - PubMed
  85. Ann N Y Acad Sci. 1995 Dec 29;774:59-72 - PubMed
  86. PLoS Biol. 2007 May;5(5):e97 - PubMed
  87. J Biol Chem. 2001 Nov 9;276(45):42549-56 - PubMed
  88. Drug Metab Dispos. 2007 May;35(5):740-6 - PubMed
  89. Endocrinology. 2005 Mar;146(3):995-1002 - PubMed
  90. Breast Cancer (Auckl). 2009 Mar 20;3:9-21 - PubMed
  91. Environ Health Perspect. 2013 Oct;121(10):1194-9 - PubMed
  92. Endocrinology. 2009 Mar;150(3):1097-107 - PubMed

Publication Types

Grant support