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Howden EJ, Ruiz-Carmona S, Claeys M, et al. Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension. Circulation. 2021;143(21):2061-2073doi: 10.1161/CIRCULATIONAHA.120.052899.
Howden, E. J., Ruiz-Carmona, S., Claeys, M., De Bosscher, R., Willems, R., Meyns, B., Verbelen, T., Maleux, G., Godinas, L., Belge, C., Bogaert, J., Claus, P., La Gerche, A., Delcroix, M., & Claessen, G. (2021). Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension. Circulation, 143(21), 2061-2073. https://doi.org/10.1161/CIRCULATIONAHA.120.052899
Howden, Erin J, et al. "Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension." Circulation vol. 143,21 (2021): 2061-2073. doi: https://doi.org/10.1161/CIRCULATIONAHA.120.052899
Howden EJ, Ruiz-Carmona S, Claeys M, De Bosscher R, Willems R, Meyns B, Verbelen T, Maleux G, Godinas L, Belge C, Bogaert J, Claus P, La Gerche A, Delcroix M, Claessen G. Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension. Circulation. 2021 May 25;143(21):2061-2073. doi: 10.1161/CIRCULATIONAHA.120.052899. Epub 2021 Apr 15. PMID: 33853383.
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Circulation. 2021 May 25;143(21):2061-2073. doi: 10.1161/CIRCULATIONAHA.120.052899. Epub 2021 Apr 15.

Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension.

Circulation

Erin J Howden, Sergio Ruiz-Carmona, Mathias Claeys, Ruben De Bosscher, Rik Willems, Bart Meyns, Tom Verbelen, Geert Maleux, Laurent Godinas, Catharina Belge, Jan Bogaert, Piet Claus, Andre La Gerche, Marion Delcroix, Guido Claessen

Affiliations

  1. Baker Heart and Diabetes Institute (E.J.H., S.R.-C., A.L.G., G.C.), Melbourne, Australia.
  2. Cambridge Baker Systems Genomics Initiative (S.R.-C.), Melbourne, Australia.
  3. Departments of Cardiovascular Sciences (M.C., R.D.B., R.W., B.M., T.V., P.C., A.L.G., G.C.), KU Leuven, Belgium.
  4. University Hospitals Leuven, Belgium (M.C., R.D.B., R.W., B.M., T.V., G.M., L.G., C.B., J.B., P.C., M.D., G.C.).
  5. Imaging & Pathology (G.M., J.B.), KU Leuven, Belgium.
  6. Chronic Diseases and Metabolism (L.G., C.B., M.D.), KU Leuven, Belgium.

PMID: 33853383 DOI: 10.1161/CIRCULATIONAHA.120.052899

Abstract

BACKGROUND: Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the pathogenesis has been attributed to central factors, including ventilation/perfusion mismatch, increased pulmonary vascular resistance, and right heart dysfunction and uncoupling. Pulmonary endarterectomy and balloon pulmonary angioplasty provide substantial improvement of functional status and hemodynamics. However, despite normalization of pulmonary hemodynamics, exercise capacity often does not return to age-predicted levels. By systematically evaluating the oxygen pathway, we aimed to elucidate the causes of functional limitations in patients with CTEPH before and after pulmonary vascular intervention.

METHODS: Using exercise cardiac magnetic resonance imaging with simultaneous invasive hemodynamic monitoring, we sought to quantify the steps of the O

RESULTS: Peak Vo

CONCLUSIONS: We demonstrated that patients with CTEPH have significant impairment of all steps in the O

Keywords: cardiac output; exercise; heart ventricles; hypertension, pulmonary; magnetic resonance imaging; systems biology

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