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Coser TA, Leitão JSV, Beltrame BM, et al. Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography. Radiol Bras. 2021;54(2):77-82doi: 10.1590/0100-3984.2020.0018.
Coser, T. A., Leitão, J. S. V., Beltrame, B. M., Selistre, L. S., & Tasso, L. (2021). Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography. Radiologia brasileira, 54(2), 77-82. https://doi.org/10.1590/0100-3984.2020.0018
Coser, Thyago A, et al. "Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography." Radiologia brasileira vol. 54,2 (2021): 77-82. doi: https://doi.org/10.1590/0100-3984.2020.0018
Coser TA, Leitão JSV, Beltrame BM, Selistre LS, Tasso L. Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography. Radiol Bras. 2021 Mar-Apr;54(2):77-82. doi: 10.1590/0100-3984.2020.0018. PMID: 33854260; PMCID: PMC8029938.
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Radiol Bras. 2021 Mar-Apr;54(2):77-82. doi: 10.1590/0100-3984.2020.0018.

Intravenous contrast use and acute kidney injury: a retrospective study of 1,238 inpatients undergoing computed tomography.

Radiologia brasileira

Thyago A Coser, Juliana S V Leitão, Betina M Beltrame, Luciano S Selistre, Leandro Tasso

Affiliations

  1. Universidade de Caxias do Sul (UCS), Caxias do Sul, RS, Brazil.

PMID: 33854260 PMCID: PMC8029938 DOI: 10.1590/0100-3984.2020.0018

Abstract

OBJECTIVE: To determine the incidence of nephropathy induced by intravenous contrast in hospitalized patients undergoing computed tomography (CT).

MATERIALS AND METHODS: This was a retrospective cohort study involving 1,238 patients who underwent CT with or without intravenous administration of a contrast agent (iopromide). The primary outcome measure was acute kidney injury (AKI), as defined by the traditional criteria-an absolute or relative increase in serum creatinine (SCr) ≥ 0.5 mg/dL or ≥ 25% over baseline, respectively, at 2-3 days after contrast administration-and the newer, Kidney Disease: Improving Global Outcomes (KDIGO) criteria-an absolute or relative increase in SCr ≥ 0.3 mg/dL or ≥ 50% over baseline, respectively, at 2-7 days after contrast administration.

RESULTS: The overall incidence of AKI was 11.52% when the KDIGO criteria were applied. Univariate logistic regression demonstrated a significant association between an absolute post-CT increase in SCr ≥ 0.5 mg/dL and AKI, although that association did not retain significance in the multivariate analysis. Multivariate logistic regression initially found an association between an absolute post-CT increase in SCr ≥ 0.3 mg/dL and advanced age, although that association was not maintained after correction. We found no association between AKI and the risk factors evaluated.

CONCLUSION: We identified no criteria for contrast-induced nephropathy after CT; nor did we find AKI to be associated with the classical risk factors.

Keywords: Acute kidney injury; Contrast media/administration & dosage; Contrast media/adverse effects; Creatinine/blood; Iodine radioisotopes; Tomography, X-ray computed

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