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Cieri-Hutcherson NE, Jaenecke A, Bahia A, et al. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy (Basel). 2021;9(2)doi: 10.3390/pharmacy9020071.
Cieri-Hutcherson, N. E., Jaenecke, A., Bahia, A., Lucas, D., Oluloro, A., Stimmel, L., & Hutcherson, T. C. (2021). Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy (Basel, Switzerland), 9(2), . https://doi.org/10.3390/pharmacy9020071
Cieri-Hutcherson, Nicole E, et al. "Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women." Pharmacy (Basel, Switzerland) vol. 9,2 (2021). doi: https://doi.org/10.3390/pharmacy9020071
Cieri-Hutcherson NE, Jaenecke A, Bahia A, Lucas D, Oluloro A, Stimmel L, Hutcherson TC. Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women. Pharmacy (Basel). 2021 Mar 27;9(2). doi: 10.3390/pharmacy9020071. PMID: 33801678; PMCID: PMC8103282.
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Pharmacy (Basel). 2021 Mar 27;9(2). doi: 10.3390/pharmacy9020071.

Systematic Review of l-Arginine for the Treatment of Hypoactive Sexual Desire Disorder and Related Conditions in Women.

Pharmacy (Basel, Switzerland)

Nicole E Cieri-Hutcherson, Andrea Jaenecke, Ajeet Bahia, Debra Lucas, Ann Oluloro, Lora Stimmel, Timothy C Hutcherson

Affiliations

  1. Department of Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA.
  2. School of Pharmacy, D'Youville College, Buffalo, NY 14201, USA.
  3. Montante Family Library, D'Youville College, Buffalo, NY 14201, USA.
  4. Department of Obstetrics and Gynecology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
  5. Department of Pharmacy Practice, School of Pharmacy, D'Youville College, Buffalo, NY 14201, USA.

PMID: 33801678 PMCID: PMC8103282 DOI: 10.3390/pharmacy9020071

Abstract

This systematic review evaluates the efficacy and safety of l-arginine alone or in combination for the treatment of women with hypoactive sexual desire disorder (HSDD) or related conditions, such as female sexual interest/arousal disorder and female sexual arousal disorder. Medline, Embase, International Pharmaceutical Abstracts, Science Direct, and the Cumulative Index to Nursing and Allied Health Literature were searched using keywords "arginine", "Lady Prelox", "ArginMax", "Stronvivo", "Ristela", "hypoactive sexual desire disorder", "female sexual interest arousal disorder", "female sexual arousal disorder", "sexual dysfunction", "sexual behavior", "dyspareunia", "libido", and permutations thereof. Relevant records were retained if they were primary literature, conducted in women with HSDD or related conditions, and published as full text in English. Five randomized controlled trials and two nonrandomized studies met eligibility criteria. Six of the seven studies reported either an increase in the total mean Female Sexual Function Index score or significant increases in multiple domains therein. One study assessed vaginal pulse amplitude and found a statistically significant increase in a combination treatment group compared to placebo. No significant side effects were reported. Four of seven studies had potential risk-of-bias concerns per Cochrane assessments. This systematic review found that combination products containing l-arginine in the form of ArginMax or Lady Prelox may be considered for the treatment of HSDD and related conditions in women regardless of age.

Keywords: arginine; dietary supplement; hypoactive sexual desire disorder; sexual dysfunction; women’s health

References

  1. J Sex Marital Ther. 2006 Oct-Dec;32(5):369-78 - PubMed
  2. Panminerva Med. 2012 Dec;54(1 Suppl 4):3-9 - PubMed
  3. J Sex Med. 2017 Dec;14(12):1463-1491 - PubMed
  4. Value Health. 2009 Jul-Aug;12(5):763-72 - PubMed
  5. Pharmacotherapy. 2013 Apr;33(4):411-21 - PubMed
  6. Hum Psychopharmacol. 2004 Dec;19(8):545-8 - PubMed
  7. Minerva Ginecol. 2013 Aug;65(4):435-44 - PubMed
  8. Minerva Ginecol. 2019 Dec;71(6):434-441 - PubMed
  9. Arch Sex Behav. 2008 Aug;37(4):530-47 - PubMed
  10. Br J Clin Pharmacol. 2008 Jan;65(1):51-9 - PubMed
  11. J Sex Med. 2018 Mar;15(3):273-283 - PubMed
  12. Urol Clin North Am. 2002 Aug;29(3):685-93 - PubMed
  13. Fitoterapia. 2000 Aug;71 Suppl 1:S1-5 - PubMed
  14. Physiol Int. 2019 Mar 1;106(1):59-69 - PubMed
  15. J Sex Med. 2012 Aug;9(8):2040-6 - PubMed
  16. J Med Econ. 2010;13(4):583-90 - PubMed
  17. Arch Sex Behav. 2002 Aug;31(4):323-32 - PubMed
  18. J Evid Based Med. 2015 Feb;8(1):2-10 - PubMed
  19. J Sex Marital Ther. 2001 Oct-Dec;27(5):541-9 - PubMed
  20. J Sex Med. 2015 Feb;12(2):576-7 - PubMed
  21. Sex Med Rev. 2016 Apr;4(2):103-120 - PubMed
  22. Mayo Clin Proc. 2018 Apr;93(4):467-487 - PubMed
  23. CNS Drugs. 2002;16(11):745-53 - PubMed
  24. Br J Nutr. 2008 Apr;99(4):855-62 - PubMed
  25. Arch Sex Behav. 1979 Jul;8(4):357-74 - PubMed
  26. Eur J Clin Nutr. 2012 May;66(5):585-90 - PubMed
  27. BMJ. 2016 Oct 12;355:i4919 - PubMed
  28. Sex Med Rev. 2015 Oct;3(4):279-288 - PubMed
  29. BMJ. 2019 Aug 28;366:l4898 - PubMed
  30. J Sex Med. 2011 Aug;8(8):2237-45 - PubMed
  31. Urol Int. 1999;63(4):220-3 - PubMed
  32. J Sex Med. 2010 Apr;7(4 Pt 1):1469-77 - PubMed
  33. Circulation. 1996 Jun 15;93(12):2135-41 - PubMed
  34. J Sex Med. 2007 Nov;4 Suppl 4:260-8 - PubMed

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