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Martiniuc A, Dumitrascu T, Ionescu M, et al. Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe. J Gastric Cancer. 2021;21(1):16-29doi: 10.5230/jgc.2021.21.e3.
Martiniuc, A., Dumitrascu, T., Ionescu, M., Tudor, S., Lacatus, M., Herlea, V., & Vasilescu, C. (2021). Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe. Journal of gastric cancer, 21(1), 16-29. https://doi.org/10.5230/jgc.2021.21.e3
Martiniuc, Alexandru, et al. "Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe." Journal of gastric cancer vol. 21,1 (2021): 16-29. doi: https://doi.org/10.5230/jgc.2021.21.e3
Martiniuc A, Dumitrascu T, Ionescu M, Tudor S, Lacatus M, Herlea V, Vasilescu C. Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe. J Gastric Cancer. 2021 Mar;21(1):16-29. doi: 10.5230/jgc.2021.21.e3. Epub 2021 Mar 18. PMID: 33854810; PMCID: PMC8020004.
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J Gastric Cancer. 2021 Mar;21(1):16-29. doi: 10.5230/jgc.2021.21.e3. Epub 2021 Mar 18.

Pancreatic Fistula after D1+/D2 Radical Gastrectomy according to the Updated International Study Group of Pancreatic Surgery Criteria: Risk Factors and Clinical Consequences. Experience of Surgeons with High Caseloads in a Single Surgical Center in Eastern Europe.

Journal of gastric cancer

Alexandru Martiniuc, Traian Dumitrascu, Mihnea Ionescu, Stefan Tudor, Monica Lacatus, Vlad Herlea, Catalin Vasilescu

Affiliations

  1. Department of General Surgery, Fundeni Clinical Institute, Bucharest, Romania.
  2. Department of Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
  3. Department of Pathology, Fundeni Clinical Institute, Bucharest, Romania.
  4. Department of Pathology, Titu Maiorescu University, Bucharest, Romania.

PMID: 33854810 PMCID: PMC8020004 DOI: 10.5230/jgc.2021.21.e3

Abstract

PURPOSE: Incidence, risk factors, and clinical consequences of pancreatic fistula (POPF) after D1+/D2 radical gastrectomy have not been well investigated in Western patients, particularly those from Eastern Europe.

MATERIALS AND METHODS: A total of 358 D1+/D2 radical gastrectomies were performed by surgeons with high caseloads in a single surgical center from 2002 to 2017. A retrospective analysis of data that were prospectively gathered in an electronic database was performed. POPF was defined and graded according to the International Study Group for Pancreatic Surgery (ISGPS) criteria. Uni- and multivariate analyses were performed to identify potential predictors of POPF. Additionally, the impact of POPF on early complications and long-term outcomes were investigated.

RESULTS: POPF was observed in 20 patients (5.6%), according to the updated ISGPS grading system. Cardiovascular comorbidities emerged as the single independent predictor of POPF formation (risk ratio, 3.051; 95% confidence interval, 1.161-8.019; P=0.024). POPF occurrence was associated with statistically significant increased rates of postoperative hemorrhage requiring re-laparotomy (P=0.029), anastomotic leak (P=0.002), 90-day mortality (P=0.036), and prolonged hospital stay (P<0.001). The long-term survival of patients with gastric adenocarcinoma was not affected by POPF (P=0.661).

CONCLUSIONS: In this large series of Eastern European patients, the clinically relevant rate of POPF after D1+/D2 radical gastrectomy was low. The presence of co-existing cardiovascular disease favored the occurrence of POPF and was associated with an increased risk of postoperative bleeding, anastomotic leak, 90-day mortality, and prolonged hospital stay. POPF was not found to affect the long-term survival of patients with gastric adenocarcinoma.

Copyright © 2021. Korean Gastric Cancer Association.

Keywords: Complications; Gastric cancer; Pancreatic fistula; Radical gastrectomy; Survival

Conflict of interest statement

Conflict of Interest: No potential conflict of interest relevant to this article was reported.

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