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Duarte-Jurado AP, Gopar-Cuevas Y, Saucedo-Cardenas O, et al. Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities. Antioxidants (Basel). 2021;10(3)doi: 10.3390/antiox10030453.
Duarte-Jurado, A. P., Gopar-Cuevas, Y., Saucedo-Cardenas, O., Loera-Arias, M. J., Montes-de-Oca-Luna, R., Garcia-Garcia, A., & Rodriguez-Rocha, H. (2021). Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities. Antioxidants (Basel, Switzerland), 10(3), . https://doi.org/10.3390/antiox10030453
Duarte-Jurado, Ana Patricia, et al. "Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities." Antioxidants (Basel, Switzerland) vol. 10,3 (2021). doi: https://doi.org/10.3390/antiox10030453
Duarte-Jurado AP, Gopar-Cuevas Y, Saucedo-Cardenas O, Loera-Arias MJ, Montes-de-Oca-Luna R, Garcia-Garcia A, Rodriguez-Rocha H. Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities. Antioxidants (Basel). 2021 Mar 15;10(3). doi: 10.3390/antiox10030453. PMID: 33803945; PMCID: PMC7998929.
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Antioxidants (Basel). 2021 Mar 15;10(3). doi: 10.3390/antiox10030453.

Antioxidant Therapeutics in Parkinson's Disease: Current Challenges and Opportunities.

Antioxidants (Basel, Switzerland)

Ana Patricia Duarte-Jurado, Yareth Gopar-Cuevas, Odila Saucedo-Cardenas, Maria de Jesus Loera-Arias, Roberto Montes-de-Oca-Luna, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha

Affiliations

  1. Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey 64460, Mexico.
  2. Centro de Investigación Biomédica del Noreste, Departamento de Genética Molecular, Instituto Mexicano del Seguro Social, Delegación Nuevo León 40080, Mexico.

PMID: 33803945 PMCID: PMC7998929 DOI: 10.3390/antiox10030453

Abstract

Oxidative stress is considered one of the pathological mechanisms that cause Parkinson's disease (PD), which has led to the investigation of several antioxidants molecules as a potential therapeutic treatment against the disease. Although preclinical studies have demonstrated the efficacy of these compounds to maintain neuronal survival and activity in PD models, these results have not been reflected in clinical trials, antioxidants have not been able to act as disease modifiers in terms of clinical symptoms. Translational medicine currently faces the challenge of redesigning clinical trials to standardize criteria when testing molecules to reduce responses' variability. Herein, we discuss current challenges and opportunities regarding several non-enzymatic antioxidants' therapeutic molecules for PD patients' potential treatment.

Keywords: Parkinson’s disease; antioxidants; clinical trials; oxidative stress

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