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Antibiotics (Basel). 2021 Mar 15;10(3). doi: 10.3390/antibiotics10030302.

Prior Antibiotic Therapy and the Onset of Healthcare-Associated Infections Sustained by Multidrug-Resistant .

Antibiotics (Basel, Switzerland)

Giuseppe Migliara, Valentina Baccolini, Claudia Isonne, Sara Cianfanelli, Carolina Di Paolo, Annamaria Mele, Lorenza Lia, Angelo Nardi, Carla Salerno, Susanna Caminada, Vittoria Cammalleri, Francesco Alessandri, Guglielmo Tellan, Giancarlo Ceccarelli, Mario Venditti, Francesco Pugliese, Carolina Marzuillo, Corrado De Vito, Maria De Giusti, Paolo Villari

Affiliations

  1. Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00185 Rome, Italy.
  2. Department of Anesthesia and Intensive Care Medicine Azienda, Universitaria-Ospedaliera Policlinico Umberto I, 00185 Rome, Italy.
  3. Department of Internal, Anesthesiological and Cardiovascular Clinical Sciences, Sapienza University of Rome, 00185 Rome, Italy.
  4. Department of General and Specialist Surgery "P. Stefanini", Sapienza University of Rome, 00185 Rome, Italy.

PMID: 33804087 PMCID: PMC8000440 DOI: 10.3390/antibiotics10030302

Abstract

Epidemiological research has demonstrated direct relationships between antibiotic consumption and the emergence of multidrug-resistant (MDR) bacteria. In this nested case-control study, we assessed whether prior exposure to antibiotic therapy and its duration affect the onset of healthcare-associated infections (HAIs) sustained by MDR

Keywords: Klebsiella pneumoniae; antibiotic exposure; healthcare-associated infections; intensive care unit; multidrug resistance

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