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Moeller S, Sridhar J, Martersteck A, et al. Functional decline in the aphasic variant of Alzheimer's disease. Alzheimers Dement. 2021;17(10):1641-1648doi: 10.1002/alz.12331.
Moeller, S., Sridhar, J., Martersteck, A., Coventry, C., Kuang, A., Zhang, H., Weintraub, S., Mesulam, M. M., & Rogalski, E. (2021). Functional decline in the aphasic variant of Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 17(10), 1641-1648. https://doi.org/10.1002/alz.12331
Moeller, Stacey, et al. "Functional decline in the aphasic variant of Alzheimer's disease." Alzheimer's & dementia : the journal of the Alzheimer's Association vol. 17,10 (2021): 1641-1648. doi: https://doi.org/10.1002/alz.12331
Moeller S, Sridhar J, Martersteck A, Coventry C, Kuang A, Zhang H, Weintraub S, Mesulam MM, Rogalski E. Functional decline in the aphasic variant of Alzheimer's disease. Alzheimers Dement. 2021 Oct;17(10):1641-1648. doi: 10.1002/alz.12331. Epub 2021 Apr 08. PMID: 33829622; PMCID: PMC8499018.
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Alzheimers Dement. 2021 Oct;17(10):1641-1648. doi: 10.1002/alz.12331. Epub 2021 Apr 08.

Functional decline in the aphasic variant of Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Stacey Moeller, Jaiashre Sridhar, Adam Martersteck, Christina Coventry, Alan Kuang, Hui Zhang, Sandra Weintraub, M-Marsel Mesulam, Emily Rogalski

Affiliations

  1. Mesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  2. Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  3. Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
  4. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

PMID: 33829622 PMCID: PMC8499018 DOI: 10.1002/alz.12331

Abstract

INTRODUCTION: Primary progressive aphasia (PPA) is a clinical dementia syndrome associated with frontotemporal lobar degeneration (FTLD) or Alzheimer's disease (AD). Impairment in activities of daily living is essential for dementia diagnosis, yet less is known about the neuropathologic impact on functional decline in PPA, especially over time.

METHODS: Activities of Daily Living Questionnaire (ADLQ) ratings were compared by suspected underlying pathology between 17 PPA

RESULTS: Groups did not differ in demographics or aphasia severity at baseline, yet overall and subdomain scores of the ADLQ were significantly worse for PPA

DISCUSSION: Functional decline appears more pronounced and disrupts more aspects of life activities for individuals with non-semantic PPA with suspected AD versus non-AD neuropathology.

© 2021 the Alzheimer's Association.

Keywords: activities of daily living; dementia; frontotemporal dementia; primary progressive aphasia

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