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Gels. 2021 Mar 24;7(2). doi: 10.3390/gels7020033.

Recent Advances of Taxol-Loaded Biocompatible Nanocarriers Embedded in Natural Polymer-Based Hydrogels.

Gels (Basel, Switzerland)

Silvia Voci, Agnese Gagliardi, Roberto Molinaro, Massimo Fresta, Donato Cosco

Affiliations

  1. Department of Health Sciences, University "Magna Græcia" of Catanzaro, Campus Universitario "S.Venuta", I-88100 Catanzaro, Italy.
  2. IRCCS Ospedale San Raffaele srl, I-20132 Milan, Italy.

PMID: 33804970 PMCID: PMC8103278 DOI: 10.3390/gels7020033

Abstract

The discovery of paclitaxel (PTX) has been a milestone in anti-cancer therapy and has promoted the development and marketing of various formulations that have revolutionized the therapeutic approach towards several malignancies. Despite its peculiar anti-cancer activity, the physico-chemical properties of PTX compromise the administration of the compound in polar media. Because of this, since the development of the first Food and Drug Administration (FDA)-approved formulation (Taxol

Keywords: cancer; hydrogels; liposomes; nanoparticles; paclitaxel; polysaccharides; proteins

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