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Starek M, Plenis A, Zagrobelna M, et al. Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases. Pharmaceutics. 2021;13(4)doi: 10.3390/pharmaceutics13040440.
Starek, M., Plenis, A., Zagrobelna, M., & Dąbrowska, M. (2021). Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases. Pharmaceutics, 13(4), . https://doi.org/10.3390/pharmaceutics13040440
Starek, Małgorzata, et al. "Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases." Pharmaceutics vol. 13,4 (2021). doi: https://doi.org/10.3390/pharmaceutics13040440
Starek M, Plenis A, Zagrobelna M, Dąbrowska M. Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases. Pharmaceutics. 2021 Mar 24;13(4). doi: 10.3390/pharmaceutics13040440. PMID: 33805056; PMCID: PMC8064060.
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Pharmaceutics. 2021 Mar 24;13(4). doi: 10.3390/pharmaceutics13040440.

Assessment of Lipophilicity Descriptors of Selected NSAIDs Obtained at Different TLC Stationary Phases.

Pharmaceutics

Małgorzata Starek, Alina Plenis, Marta Zagrobelna, Monika Dąbrowska

Affiliations

  1. Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland.
  2. Department of Pharmaceutical Chemistry, Medical University of Gda?sk, Hallera 107, 80-416 Gda?sk, Poland.

PMID: 33805056 PMCID: PMC8064060 DOI: 10.3390/pharmaceutics13040440

Abstract

Lipophilicity study of selected NSAIDs, the group of the bioactive compounds usually used in humans and animals medicine, with the use of experimental and calculation methods was evaluated. LogP values are proposed and compared as descriptors of the lipophilicity of eleven compounds (from oxicams and coxibs). Obtained data were designated by thin-layer chromatography (TLC) in various chromatographic conditions, with stationary phases with different properties. The mobile phase systems were prepared by mixing the respective amounts of water and organic modifier, methanol and acetone, in the range of 30 to 80% (

Keywords: NSAIDs; chemometric methods; lipophilicity; stationary phases; thin-layer chromatography

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