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Reddy V, Hernandez A, Grossman L, et al. Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder. Cureus. 2021;13(3):e13846doi: 10.7759/cureus.13846.
Reddy, V., Hernandez, A., Grossman, L., Angelo, D., & Frunzi, J. (2021). Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder. Cureus, 13(3), e13846. https://doi.org/10.7759/cureus.13846
Reddy, Varun, et al. "Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder." Cureus vol. 13,3 (2021): e13846. doi: https://doi.org/10.7759/cureus.13846
Reddy V, Hernandez A, Grossman L, Angelo D, Frunzi J. Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder. Cureus. 2021 Mar 12;13(3):e13846. doi: 10.7759/cureus.13846. PMID: 33859899; PMCID: PMC8038922.
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Cureus. 2021 Mar 12;13(3):e13846. doi: 10.7759/cureus.13846.

Memantine Usage for Management of Korsakoff Syndrome in the Setting of Chronic Alcohol Use and Unspecified Eating Disorder.

Cureus

Varun Reddy, Andrea Hernandez, Leah Grossman, Debra Angelo, Johnathan Frunzi

Affiliations

  1. Internal Medicine, Medical Center of Trinity, Trinity, USA.

PMID: 33859899 PMCID: PMC8038922 DOI: 10.7759/cureus.13846

Abstract

Korsakoff syndrome is a neuropsychiatric condition frequently seen as a progression of Wernicke's encephalopathy and is often associated with long-term alcohol abuse. It is characterized by further cognitive impairments, such as indiscriminate anterograde and retrograde amnesia, in addition to executive function deficits. As the syndrome is a result of severe thiamine deficiency, its management primarily focuses on nutritional replenishment and electrolyte maintenance. In recent years, a few published reports have detailed the off-label use of Food and Drug Administration (FDA) approved drugs for Alzheimer's in an attempt to treat neurocognitive deficits associated with Korsakoff patients. In this particular case, we note subjective improvement in cognition after initiating memantine, an N-Methyl-d-aspartate (NMDA) receptor antagonist.

Copyright © 2021, Reddy et al.

Keywords: memantine; nmda receptor antagonist; quetapine; wernicke-korsakoff syndrome

Conflict of interest statement

The authors have declared that no competing interests exist.

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