Stem Cells. 2021 Sep;39(9):1207-1220. doi: 10.1002/stem.3385. Epub 2021 Apr 29.

Cell-intrinsic Wnt4 promotes hematopoietic stem and progenitor cell self-renewal.

Stem cells (Dayton, Ohio)

Roxann Hétu-Arbour, Mouna Tlili, Fabio Luiz Bandeira Ferreira, Belma Melda Abidin, Edward O Kwarteng, Krista M Heinonen

PMID: 33882146 DOI: 10.1002/stem.3385

Abstract

Although intracellular Wnt signaling pathways need to be tightly regulated to promote hematopoietic stem cell self-renewal, the source and identity of important Wnt ligands in the bone marrow is still largely unknown. The noncanonical ligand Wnt4 is expressed in the bone marrow as well as in the stroma, and its overexpression in fetal liver cells facilitates thymic recovery; however, its impact on adult hematopoietic stem cell function remains unclear. Here, we report that the deletion of Wnt4 from hematopoietic cells in mice (Wnt4

© 2021 AlphaMed Press.

Keywords: Wnt signaling; bone marrow transplant; hematopoietic recovery; hematopoietic stem cells; lipopolysaccharide

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Publication Types

• Journal Article

Grant support

• 31377/Canada Foundation for Innovation
• 32598/Fonds de Recherche du Québec - Santé
• 2018-05258/Natural Sciences and Engineering Research Council of Canada
• 419226-2012/Natural Sciences and Engineering Research Council of Canada
• The Cole Foundation