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Maduro AT, Luís C, Soares R. Ageing, cellular senescence and the impact of diet: an overview. Porto Biomed J. 2021;6(1):e120doi: 10.1097/j.pbj.0000000000000120.
Maduro, A. T., Luís, C., & Soares, R. (2021). Ageing, cellular senescence and the impact of diet: an overview. Porto biomedical journal, 6(1), e120. https://doi.org/10.1097/j.pbj.0000000000000120
Maduro, Ana T, et al. "Ageing, cellular senescence and the impact of diet: an overview." Porto biomedical journal vol. 6,1 (2021): e120. doi: https://doi.org/10.1097/j.pbj.0000000000000120
Maduro AT, Luís C, Soares R. Ageing, cellular senescence and the impact of diet: an overview. Porto Biomed J. 2021 Feb 11;6(1):e120. doi: 10.1097/j.pbj.0000000000000120. eCollection 2021. PMID: 33884316; PMCID: PMC8055488.
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Porto Biomed J. 2021 Feb 11;6(1):e120. doi: 10.1097/j.pbj.0000000000000120. eCollection 2021.

Ageing, cellular senescence and the impact of diet: an overview.

Porto biomedical journal

Ana T Maduro, Carla Luís, Raquel Soares

Affiliations

  1. Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Coimbra.
  2. Biochemistry Unit, Department of Biomedicine, Faculty of Medicine, University of Porto.
  3. i3S, Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.

PMID: 33884316 PMCID: PMC8055488 DOI: 10.1097/j.pbj.0000000000000120

Abstract

Ageing is a risk factor for chronic diseases including cancer, cardiovascular diseases, neurodegenerative disorders, and metabolic syndrome. Among others, senescence mechanisms have become a target of huge research on the topic of the ageing process. Cellular senescence is a state of an irreversible growth arrest that occurs in response to various forms of cellular stress and is characterized by a pro-inflammatory secretory phenotype. Multiple studies showed that cellular senescence occurs in both physiological and pathophysiological conditions. Senescent cells accumulate with ageing and can contribute to age-related decline in tissue function. Obesity is a metabolic condition that can accelerate the ageing process by promoting a premature induction of the senescent state of the cells. In contrast, caloric restriction without malnutrition is currently the most effective non-genetic intervention to delay ageing, and its potential in decreasing the cellular senescent burden is suggested. Here, it will be highlighted the cellular and molecular mechanisms involved in cellular senescence and discussed some of the research that is being done about how environmental conditions such as diet can affect the accumulation of senescent cells.

Copyright © 2021 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of PBJ-Associação Porto Biomedical/Porto Biomedical Society. All rights reserved.

Keywords: ageing; caloric restriction; caloric restriction mimetics; cellular senescence; obesity

Conflict of interest statement

There are no conflicts of interest regarding this paper.

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