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Ahmad A, Ishtiaq SM, Khan JA, et al. COVID-19 and comorbidities of hepatic diseases in a global perspective. World J Gastroenterol. 2021;27(13):1296-1310doi: 10.3748/wjg.v27.i13.1296.
Ahmad, A., Ishtiaq, S. M., Khan, J. A., Aslam, R., Ali, S., & Arshad, M. I. (2021). COVID-19 and comorbidities of hepatic diseases in a global perspective. World journal of gastroenterology, 27(13), 1296-1310. https://doi.org/10.3748/wjg.v27.i13.1296
Ahmad, Aqsa, et al. "COVID-19 and comorbidities of hepatic diseases in a global perspective." World journal of gastroenterology vol. 27,13 (2021): 1296-1310. doi: https://doi.org/10.3748/wjg.v27.i13.1296
Ahmad A, Ishtiaq SM, Khan JA, Aslam R, Ali S, Arshad MI. COVID-19 and comorbidities of hepatic diseases in a global perspective. World J Gastroenterol. 2021 Apr 07;27(13):1296-1310. doi: 10.3748/wjg.v27.i13.1296. PMID: 33833483; PMCID: PMC8015303.
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World J Gastroenterol. 2021 Apr 07;27(13):1296-1310. doi: 10.3748/wjg.v27.i13.1296.

COVID-19 and comorbidities of hepatic diseases in a global perspective.

World journal of gastroenterology

Aqsa Ahmad, Syeda Momna Ishtiaq, Junaid Ali Khan, Rizwan Aslam, Sultan Ali, Muhammad Imran Arshad

Affiliations

  1. Institute of Microbiology, University of Agriculture Faisalabad, Faisalabad 38040, Punjab, Pakistan.
  2. Institute of Physiology and Pharmacology, University of Agriculture Faisalabad, Faisalabad 38040, Punjab, Pakistan.
  3. Institute of Microbiology, University of Agriculture Faisalabad, Faisalabad 38040, Punjab, Pakistan. [email protected].

PMID: 33833483 PMCID: PMC8015303 DOI: 10.3748/wjg.v27.i13.1296

Abstract

The worldwide outbreak of coronavirus disease 2019 (COVID-19) has challenged the priorities of healthcare system in terms of different clinical management and infection transmission, particularly those related to hepatic-disease comorbidities. Epidemiological data evidenced that COVID-19 patients with altered liver function because of hepatitis infection and cholestasis have an adverse prognosis and experience worse health outcomes. COVID-19-associated liver injury is correlated with various liver diseases following a severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) infection that can progress during the treatment of COVID-19 patients with or without pre-existing liver disease. SARS-CoV-2 can induce liver injury in a number of ways including direct cytopathic effect of the virus on cholangiocytes/hepatocytes, immune-mediated damage, hypoxia, and sepsis. Indeed, immediate cytopathogenic effects of SARS-CoV-2

©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

Keywords: COVID-19; Epidemiology; Liver disease; Pathophysiology; Prophylaxis

Conflict of interest statement

Conflict-of-interest statement: The authors declare no competing and financial conflict of interests.

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