Display options
Cite
Maciążek-Jurczyk M, Morak-Młodawska B, Jeleń M, et al. The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity. Pharmaceuticals (Basel). 2021;14(3)doi: 10.3390/ph14030285.
Maciążek-Jurczyk, M., Morak-Młodawska, B., Jeleń, M., Kopeć, W., Szkudlarek, A., Owczarzy, A., Kulig, K., Rogóż, W., & Pożycka, J. (2021). The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity. Pharmaceuticals (Basel, Switzerland), 14(3), . https://doi.org/10.3390/ph14030285
Maciążek-Jurczyk, Małgorzata, et al. "The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity." Pharmaceuticals (Basel, Switzerland) vol. 14,3 (2021). doi: https://doi.org/10.3390/ph14030285
Maciążek-Jurczyk M, Morak-Młodawska B, Jeleń M, Kopeć W, Szkudlarek A, Owczarzy A, Kulig K, Rogóż W, Pożycka J. The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity. Pharmaceuticals (Basel). 2021 Mar 23;14(3). doi: 10.3390/ph14030285. PMID: 33806875; PMCID: PMC8005128.
Copy Download .nbib Format: NLM
Share it on

Pharmaceuticals (Basel). 2021 Mar 23;14(3). doi: 10.3390/ph14030285.

The Influence of Oxidative Stress on Serum Albumin Structure as a Carrier of Selected Diazaphenothiazine with Potential Anticancer Activity.

Pharmaceuticals (Basel, Switzerland)

Małgorzata Maciążek-Jurczyk, Beata Morak-Młodawska, Małgorzata Jeleń, Wiktoria Kopeć, Agnieszka Szkudlarek, Aleksandra Owczarzy, Karolina Kulig, Wojciech Rogóż, Jadwiga Pożycka

Affiliations

  1. Department of Physical Pharmacy, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.
  2. Department of Organic Chemistry, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, 40-055 Katowice, Poland.

PMID: 33806875 PMCID: PMC8005128 DOI: 10.3390/ph14030285

Abstract

Albumin is one of the most important proteins in human blood. Among its multiple functions, drug binding is crucial in terms of drug distribution in human body. This protein undergoes many modifications that are certain to influence protein activity and affect its structure. One such reaction is albumin oxidation. Chloramine T is a strong oxidant. Solutions of human serum albumin, both non-modified and modified by chloramine T, were examined with the use of fluorescence, absorption and circular dichroism (CD) spectroscopy. 10

Keywords: 10H-3,6-diazaphenothiazine; human serum albumin; oxidation; spectroscopic methods

References

  1. Mol Aspects Med. 2012 Jun;33(3):209-90 - PubMed
  2. Molecules. 2020 Jan 31;25(3): - PubMed
  3. Biochem Pharmacol. 1985 Jun 1;34(11):1999-2005 - PubMed
  4. Br J Pharmacol. 2007 Jul;151(5):580-90 - PubMed
  5. Biochim Biophys Acta. 2013 Dec;1830(12):5435-43 - PubMed
  6. Biopolymers. 2008 May;89(5):392-400 - PubMed
  7. Nat Protoc. 2006;1(6):2876-90 - PubMed
  8. Pharm Res. 2003 Apr;20(4):684-92 - PubMed
  9. Biochem Biophys Rep. 2018 May 11;14:155-160 - PubMed
  10. Arch Biochem Biophys. 1959 May;82(1):70-7 - PubMed
  11. Biochemistry. 1973 Oct 9;12(21):4171-9 - PubMed
  12. Hepatol Int. 2016 Jan;10(1):124-32 - PubMed
  13. Mol Pharm. 2013 May 6;10(5):1668-82 - PubMed
  14. Med Sci Monit. 2002 Jul;8(7):BR266-71 - PubMed
  15. J Struct Biol. 2011 Apr;174(1):84-91 - PubMed
  16. Protein Eng. 1999 Jun;12(6):439-46 - PubMed
  17. Biochemistry. 1971 Aug 3;10(16):3065-9 - PubMed
  18. Expert Opin Drug Deliv. 2016 Nov;13(11):1609-1623 - PubMed
  19. FEBS J. 2005 Jan;272(2):353-62 - PubMed
  20. Anal Biochem. 1994 Oct;222(1):176-84 - PubMed
  21. Int J Mol Sci. 2013 May 23;14(6):10694-709 - PubMed
  22. Chem Biol Interact. 2006 Mar 10;160(1):1-40 - PubMed
  23. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Feb 5;136 Pt B:265-82 - PubMed
  24. J Biol Chem. 1991 Mar 15;266(8):4692-9 - PubMed
  25. Clin Chim Acta. 2011 Nov 20;412(23-24):2105-16 - PubMed
  26. Ageing Res Rev. 2013 Jan;12(1):376-90 - PubMed
  27. Pharm Res. 1998 Apr;15(4):592-8 - PubMed
  28. Spectrochim Acta A Mol Biomol Spectrosc. 2018 Jan 5;188:675-683 - PubMed
  29. Anal Bioanal Chem. 2002 Jul;373(4-5):266-76 - PubMed
  30. Biopolymers. 2012 Nov;97(11):889-98 - PubMed
  31. Drug Des Devel Ther. 2017 Oct 24;11:3045-3063 - PubMed
  32. Eur J Med Chem. 2011 Aug;46(8):3179-89 - PubMed
  33. IUBMB Life. 2011 Apr;63(4):277-85 - PubMed
  34. Biochim Biophys Acta. 2013 Dec;1830(12):5465-72 - PubMed
  35. Methods Enzymol. 1990;183:63-98 - PubMed
  36. Mol Pharmacol. 1975 Nov;11(6):824-32 - PubMed
  37. J Enzyme Inhib Med Chem. 2016 Dec;31(6):1512-9 - PubMed
  38. Adv Protein Chem. 1994;45:153-203 - PubMed
  39. Luminescence. 2002 Jan-Feb;17(1):19-42 - PubMed
  40. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5;152:537-50 - PubMed
  41. Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 5;138:925-31 - PubMed
  42. Adv Cancer Res. 2013;119:107-25 - PubMed
  43. Biol Pharm Bull. 2002 Jun;25(6):695-704 - PubMed
  44. Science. 1968 Nov 1;162(3853):526-33 - PubMed
  45. Anal Biochem. 2000 Dec 15;287(2):252-60 - PubMed
  46. Drug Discov Today. 2011 Feb;16(3-4):119-31 - PubMed
  47. Molecules. 2020 May 17;25(10): - PubMed
  48. Nature. 1992 Jul 16;358(6383):209-15 - PubMed

Publication Types