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Lui SSY, Lam JPY, Lam JWS, et al. Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients. Asian J Psychiatr. 2021;60:102644doi: 10.1016/j.ajp.2021.102644.
Lui, S. S. Y., Lam, J. P. Y., Lam, J. W. S., Chui, W. W. H., Mui, J. H. C., Siu, B. W. M., Cheng, K. M., Cheung, E. F. C., & Chan, R. C. K. (2021). Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients. Asian journal of psychiatry, 60102644. https://doi.org/10.1016/j.ajp.2021.102644
Lui, Simon S Y, et al. "Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients." Asian journal of psychiatry vol. 60 (2021): 102644. doi: https://doi.org/10.1016/j.ajp.2021.102644
Lui SSY, Lam JPY, Lam JWS, Chui WWH, Mui JHC, Siu BWM, Cheng KM, Cheung EFC, Chan RCK. Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients. Asian J Psychiatr. 2021 Jun;60:102644. doi: 10.1016/j.ajp.2021.102644. Epub 2021 Apr 06. PMID: 33862475.
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Asian J Psychiatr. 2021 Jun;60:102644. doi: 10.1016/j.ajp.2021.102644. Epub 2021 Apr 06.

Cognitive insight is correlated with cognitive impairments and contributes to medication adherence in schizophrenia patients.

Asian journal of psychiatry

Simon S Y Lui, Jessica P Y Lam, Joanna W S Lam, William W H Chui, Jolene H C Mui, Bonnie W M Siu, K M Cheng, Eric F C Cheung, Raymond C K Chan

Affiliations

  1. Department of Psychiatry, The University of Hong Kong, Hong Kong Special Administrative Region, China; Castle Peak Hospital, Hong Kong Special Administrative Region, China. Electronic address: [email protected].
  2. Castle Peak Hospital, Hong Kong Special Administrative Region, China.
  3. Neuropsychology and Applied Cognitive Neuroscience Laboratory, CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing, China.

PMID: 33862475 DOI: 10.1016/j.ajp.2021.102644

Abstract

OBJECTIVE: Cognitive insight refers to the ability to distance oneself from and evaluate one's own beliefs and interpretations. Little is known about whether cognitive insight could influence medication adherence in schizophrenia patients. This study examined the role of cognitive insight in medication adherence and how it would interact with neuropsychological functions.

METHODS: Ninety clinically-stable schizophrenia patients completed the Beck's Cognitive Insight Scale (BCIS) and tasks measuring prospective (PM) and other neurocognitive functions. Medication adherence was estimated using a multi-axial method comprising interview, clinician-rating, pharmacy refill record and pill counting. Correlational and regression analyses were conducted to examine whether cognitive insight and PM would be associated with mediation adherence. Post-hoc mediational analysis was performed to examine the interplay between cognitive insight, PM and medication adherence.

RESULTS: Clinical insight and cognitive insight together significantly influenced participants' medication adherence, after neurocognitive functions and psychopathology were accounted for. Time-based PM, compared with other neurocognitive functions, affected medication adherence more strongly.

CONCLUSIONS: Cognitive insight complements clinical insight in affecting medication adherence in schizophrenia patients.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Cognitive insight; Medication adherence; Prospective memory; Schizophrenia

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