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Rashid MY, Noor A, Patel V, et al. Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Cureus. 2021;13(3):e13724doi: 10.7759/cureus.13724.
Rashid, M. Y., Noor, A., Patel, V., Henin, S., Cuello-Ramírez, A., Al Kaabi, A. S., Gnawali, A., & Mostafa, J. A. (2021). Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Cureus, 13(3), e13724. https://doi.org/10.7759/cureus.13724
Rashid, Mohammed Y, et al. "Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis." Cureus vol. 13,3 (2021): e13724. doi: https://doi.org/10.7759/cureus.13724
Rashid MY, Noor A, Patel V, Henin S, Cuello-Ramírez A, Al Kaabi AS, Gnawali A, Mostafa JA. Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis. Cureus. 2021 Mar 05;13(3):e13724. doi: 10.7759/cureus.13724. PMID: 33833935; PMCID: PMC8018875.
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Cureus. 2021 Mar 05;13(3):e13724. doi: 10.7759/cureus.13724.

Role of SCO-792, A Novel Enteropeptidase Inhibitor, In the Prevention of Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis.

Cureus

Mohammed Y Rashid, Asfa Noor, Viral Patel, Shereen Henin, Alejandrina Cuello-Ramírez, Anoud S Al Kaabi, Anupa Gnawali, Jihan A Mostafa

Affiliations

  1. General Surgery, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
  2. Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
  3. Internal Medicine/Pediatrics, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
  4. Neonatology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
  5. Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
  6. Psychotherapy and Research, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

PMID: 33833935 PMCID: PMC8018875 DOI: 10.7759/cureus.13724

Abstract

Acute pancreatitis is the most common iatrogenic dilemma of endoscopic retrograde cholangiopancreatography, and it is associated with significant morbidity and mortality. Several factors have been implicated in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis, and preventive measures were practiced accordingly. This study aims to refine the potential mechanisms that trigger post-endoscopic retrograde cholangiopancreatography pancreatitis and define the role of enteropeptidase in the pathogenesis of post-endoscopic retrograde cholangiopancreatography pancreatitis. Furthermore, address the role of a new novel medication known as SCO-792, a potent enteropeptidase inhibitor, in the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis. Post-endoscopic retrograde cholangiopancreatography pancreatitis is caused by premature activation of the pancreatic enzymes within the pancreatic parenchyma. This activation is either an autoactivation due to direct provocation of intra-acinar enzymes as a result of the procedure or due to activation by enterpeptidase, a rate-limiting enzyme. Endoscopic retrograde cholangiopancreatography interjects duodenal juice that is rich in enterokinase into the pancreatic-biliary tract, which in turn leads to intra-ductal activation of trypsinogen and subsequent enzymes. Given the vital role of enterokinase in initiating the pathogenesis of pancreatitis, enteropeptidase inhibition may prevent and reduce the severity of post-endoscopic retrograde cholangiopancreatography pancreatitis. SCO-792, a novel enteropeptidase inhibitor, is developed by SCOHIA Pharma, and pre-clinical trials confirmed its efficacy in inhibiting enteropeptidase. Studies are needed to confirm the efficacy of enteropeptidase inhibitors in preventing post-endoscopic retrograde cholangiopancreatography pancreatitis.

Copyright © 2021, Rashid et al.

Keywords: acute pancreatitis; enteropeptidase; enteropeptidase inhibitor; post-endoscopic retrograde cholangiopancreatography pancreatitis; sco-792

Conflict of interest statement

The authors have declared that no competing interests exist.

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