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Kornum DS, Terkelsen AJ, Bertoli D, et al. Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives. J Clin Med. 2021;10(7)doi: 10.3390/jcm10071392.
Kornum, D. S., Terkelsen, A. J., Bertoli, D., Klinge, M. W., Høyer, K. L., Kufaishi, H. H. A., Borghammer, P., Drewes, A. M., Brock, C., & Krogh, K. (2021). Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives. Journal of clinical medicine, 10(7), . https://doi.org/10.3390/jcm10071392
Kornum, Ditte S, et al. "Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives." Journal of clinical medicine vol. 10,7 (2021). doi: https://doi.org/10.3390/jcm10071392
Kornum DS, Terkelsen AJ, Bertoli D, Klinge MW, Høyer KL, Kufaishi HHA, Borghammer P, Drewes AM, Brock C, Krogh K. Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives. J Clin Med. 2021 Mar 31;10(7). doi: 10.3390/jcm10071392. PMID: 33807256; PMCID: PMC8037288.
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J Clin Med. 2021 Mar 31;10(7). doi: 10.3390/jcm10071392.

Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.

Journal of clinical medicine

Ditte S Kornum, Astrid J Terkelsen, Davide Bertoli, Mette W Klinge, Katrine L Høyer, Huda H A Kufaishi, Per Borghammer, Asbjørn M Drewes, Christina Brock, Klaus Krogh

Affiliations

  1. Department of Hepatology and Gastroenterology, Aarhus University Hospital, DK8200 Aarhus, Denmark.
  2. Steno Diabetes Centre Aarhus, Aarhus University Hospital, DK8200 Aarhus, Denmark.
  3. Department of Neurology, Aarhus University Hospital, DK8200 Aarhus, Denmark.
  4. Mech-Sense, Department of Gastroenterology and Hepatology, Aalborg University Hospital, DK9100 Aalborg, Denmark.
  5. Steno Diabetes Centre Copenhagen, Gentofte Hospital, DK2820 Gentofte, Denmark.
  6. Department of Nuclear Medicine and PET-Centre, Aarhus University Hospital, DK8200 Aarhus, Denmark.
  7. Steno Diabetes Centre North Jutland, Aalborg University Hospital, DK9100 Aalborg, Denmark.

PMID: 33807256 PMCID: PMC8037288 DOI: 10.3390/jcm10071392

Abstract

The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson's disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.

Keywords: Parkinson’s disease; autonomic dysfunction; breath test; diabetes mellitus; gastrointestinal; imaging; investigations; manometry; motility

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