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Oncol Lett. 2021 Jun;21(6):446. doi: 10.3892/ol.2021.12707. Epub 2021 Apr 06.

Analysis of radiotherapy-induced alteration of CD8.

Oncology letters

Yasumasa Mori, Hiro Sato, Takuya Kumazawa, Tiara Bunga Mayang Permata, Yuya Yoshimoto, Kazutoshi Murata, Shin-Ei Noda, Takuya Kaminuma, Ken Ando, Takahiro Oike, Noriyuki Okonogi, Kohei Okada, Sangeeta Kakoti, Keiji Suzuki, Hayato Ikota, Hideaki Yokoo, Takashi Nakano, Tatsuya Ohno, Atsushi Shibata

Affiliations

  1. Department of Radiation Oncology, Graduate School of Medicine, Gunma University, Maebashi, Gunma 371-8511, Japan.
  2. Department of Radiotherapy, Saitama Cancer Center, Ina, Saitama 362-0806, Japan.
  3. Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr Cipto Mangunkusumo Hospital, Jakarta 10430, Indonesia.
  4. Department of Radiation Oncology, Fukushima Medical University, Fukushima 960-1247, Japan.
  5. Department of Radiation Oncology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Hidaka, Saitama 350-1298, Japan.
  6. National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan.
  7. Signal Transduction Program, Gunma University Initiative for Advanced Research, Gunma University, Maebashi, Gunma 371-8511, Japan.
  8. Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan.
  9. Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma 371-8511, Japan.
  10. Department of Human Pathology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.

PMID: 33868484 PMCID: PMC8045163 DOI: 10.3892/ol.2021.12707

Abstract

Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8

Copyright © 2021, Spandidos Publications.

Keywords: CD8+ T cell; cervical cancer; immune modulation; programmed death-ligand 1; radiotherapy; tumor microenvironment

Conflict of interest statement

The authors declare that they have no competing interests.

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