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Huang Y, Wang J, Jiang K, et al. Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions. J Control Release. 2021;334:127-137doi: 10.1016/j.jconrel.2021.04.016.
Huang, Y., Wang, J., Jiang, K., & Chung, E. J. (2021). Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions. Journal of controlled release : official journal of the Controlled Release Society, 334127-137. https://doi.org/10.1016/j.jconrel.2021.04.016
Huang, Yi, et al. "Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions." Journal of controlled release : official journal of the Controlled Release Society vol. 334 (2021): 127-137. doi: https://doi.org/10.1016/j.jconrel.2021.04.016
Huang Y, Wang J, Jiang K, Chung EJ. Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions. J Control Release. 2021 Jun 10;334:127-137. doi: 10.1016/j.jconrel.2021.04.016. Epub 2021 Apr 20. PMID: 33892054; PMCID: PMC8192458.
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J Control Release. 2021 Jun 10;334:127-137. doi: 10.1016/j.jconrel.2021.04.016. Epub 2021 Apr 20.

Improving kidney targeting: The influence of nanoparticle physicochemical properties on kidney interactions.

Journal of controlled release : official journal of the Controlled Release Society

Yi Huang, Jonathan Wang, Kairui Jiang, Eun Ji Chung

Affiliations

  1. Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA.
  2. Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA; Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA, USA; Department of Medicine, Division of Nephrology and Hypertension, University of Southern California, Los Angeles, CA, USA; Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, University of Southern California, Los Angeles, CA, USA. Electronic address: [email protected].

PMID: 33892054 PMCID: PMC8192458 DOI: 10.1016/j.jconrel.2021.04.016

Abstract

Kidney-targeted nanoparticles have become of recent interest due to their potential to deliver drugs directly to diseased tissue, decrease off-target adverse effects, and increase overall tolerability to patients with chronic kidney disease that require lifelong drug exposure. Given the physicochemical properties of nanoparticles can drastically affect their ability to extravasate past cellular and biological barriers and access the kidneys, we surveyed the literature from the past decade and analyzed how nanoparticle size, charge, shape, and material density affects passage and interaction with the kidneys. Specifically, we found that nanoparticle size impacted the mechanism of nanoparticle entry into the kidneys such as glomerular filtration or tubular secretion. In addition, we found charge, aspect ratio, and material density influences nanoparticle renal retention and provide insights for designing nanoparticles for passive kidney targeting. Finally, we conclude by highlighting active targeting strategies that bolster kidney retention and discuss the clinical status of nanomedicine for kidney diseases.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Acute kidney disease; Chronic kidney disease; Nanoparticle; Renal clearance; Targeted drug delivery

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