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Wier J, Lacey A, Yenikomshian H, et al. A Fatal Case of Toxic Epidermal Necrolysis Combined With Vanishing Bile Duct Syndrome and Hemophagocytic Lymphohistiocytosis. J Burn Care Res. 2021;42(5):1043-1046doi: 10.1093/jbcr/irab058.
Wier, J., Lacey, A., Yenikomshian, H., & Gillenwater, J. (2021). A Fatal Case of Toxic Epidermal Necrolysis Combined With Vanishing Bile Duct Syndrome and Hemophagocytic Lymphohistiocytosis. Journal of burn care & research : official publication of the American Burn Association, 42(5), 1043-1046. https://doi.org/10.1093/jbcr/irab058
Wier, Julian, et al. "A Fatal Case of Toxic Epidermal Necrolysis Combined With Vanishing Bile Duct Syndrome and Hemophagocytic Lymphohistiocytosis." Journal of burn care & research : official publication of the American Burn Association vol. 42,5 (2021): 1043-1046. doi: https://doi.org/10.1093/jbcr/irab058
Wier J, Lacey A, Yenikomshian H, Gillenwater J. A Fatal Case of Toxic Epidermal Necrolysis Combined With Vanishing Bile Duct Syndrome and Hemophagocytic Lymphohistiocytosis. J Burn Care Res. 2021 Sep 30;42(5):1043-1046. doi: 10.1093/jbcr/irab058. PMID: 33904918.
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J Burn Care Res. 2021 Sep 30;42(5):1043-1046. doi: 10.1093/jbcr/irab058.

A Fatal Case of Toxic Epidermal Necrolysis Combined With Vanishing Bile Duct Syndrome and Hemophagocytic Lymphohistiocytosis.

Journal of burn care & research : official publication of the American Burn Association

Julian Wier, Alexandra Lacey, Haig Yenikomshian, Justin Gillenwater

Affiliations

  1. Keck School of Medicine, University of Southern California, Los Angeles, USA.
  2. Division of Plastic and Reconstructive Surgery, Keck School of Medicine, University of Southern California, Los Angeles, USA.
  3. Los Angeles County Regional Burn Center, Los Angeles County + University of Southern California Medical Center, USA.

PMID: 33904918 DOI: 10.1093/jbcr/irab058

Abstract

This case report describes a case of fatal toxic epidermal necrolysis complicated by both vanishing bile duct syndrome and hemophagocytic lymphohistiocytosis due to Influenza B infection. Here we highlight the potential for complex morbidity secondary to underlying autoimmune hypersensitivity. Furthermore, the stepwise progression of these pathologies is noted, with the initial epidermal lesions first progressing to cholestatic injury and then subsequently to the hematologic manifestations.

Published by Oxford University Press on behalf of the American Burn Association 2021.

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