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Threlfell S, Mohammadi AS, Ryan BJ, et al. Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol. Front Cell Neurosci. 2021;15:658244doi: 10.3389/fncel.2021.658244.
Threlfell, S., Mohammadi, A. S., Ryan, B. J., Connor-Robson, N., Platt, N. J., Anand, R., Serres, F., Sharp, T., Bengoa-Vergniory, N., Wade-Martins, R., Ewing, A., Cragg, S. J., & Brimblecombe, K. R. (2021). Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol. Frontiers in cellular neuroscience, 15658244. https://doi.org/10.3389/fncel.2021.658244
Threlfell, Sarah, et al. "Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol." Frontiers in cellular neuroscience vol. 15 (2021): 658244. doi: https://doi.org/10.3389/fncel.2021.658244
Threlfell S, Mohammadi AS, Ryan BJ, Connor-Robson N, Platt NJ, Anand R, Serres F, Sharp T, Bengoa-Vergniory N, Wade-Martins R, Ewing A, Cragg SJ, Brimblecombe KR. Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol. Front Cell Neurosci. 2021 Apr 15;15:658244. doi: 10.3389/fncel.2021.658244. eCollection 2021. PMID: 33935654; PMCID: PMC8081845.
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Front Cell Neurosci. 2021 Apr 15;15:658244. doi: 10.3389/fncel.2021.658244. eCollection 2021.

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol.

Frontiers in cellular neuroscience

Sarah Threlfell, Amir Saeid Mohammadi, Brent J Ryan, Natalie Connor-Robson, Nicola J Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Richard Wade-Martins, Andrew Ewing, Stephanie J Cragg, Katherine R Brimblecombe

Affiliations

  1. Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
  2. Oxford Parkinson's Disease Centre, Medical Sciences Division, University of Oxford, Oxford, United Kingdom.
  3. Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden.
  4. University Department of Pharmacology, University of Oxford, Oxford, United Kingdom.
  5. Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden.

PMID: 33935654 PMCID: PMC8081845 DOI: 10.3389/fncel.2021.658244

Abstract

Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson's disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and molecular pathology of idiopathic and familial PD. Here, we tested whether DAT function in governing dopamine (DA) uptake and release is modified in a human-α-synuclein-overexpressing (

Copyright © 2021 Threlfell, Mohammadi, Ryan, Connor-Robson, Platt, Anand, Serres, Sharp, Bengoa-Vergniory, Wade-Martins, Ewing, Cragg and Brimblecombe.

Keywords: Parkinson’s disease; alpha-synuclein (SNCA); cholesteroI; dopamine transporter (DAT); dopamine uptake; early stage parkinsonism; galactoceramide; striatum

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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