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Revuelta Iniesta R, Causer AJ, Arregui-Fresneda I, et al. The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study. J Hum Nutr Diet. 2021;doi: 10.1111/jhn.12906.
Revuelta Iniesta, R., Causer, A. J., Arregui-Fresneda, I., Connett, G., Allenby, M. I., Daniels, T., Carroll, M. P., Urquhart, D. S., & Saynor, Z. L. (2021). The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study. Journal of human nutrition and dietetics : the official journal of the British Dietetic Association, . https://doi.org/10.1111/jhn.12906
Revuelta Iniesta, Raquel, et al. "The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study." Journal of human nutrition and dietetics : the official journal of the British Dietetic Association vol. (2021). doi: https://doi.org/10.1111/jhn.12906
Revuelta Iniesta R, Causer AJ, Arregui-Fresneda I, Connett G, Allenby MI, Daniels T, Carroll MP, Urquhart DS, Saynor ZL. The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study. J Hum Nutr Diet. 2021 Apr 28; doi: 10.1111/jhn.12906. Epub 2021 Apr 28. PMID: 33908093.
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J Hum Nutr Diet. 2021 Apr 28; doi: 10.1111/jhn.12906. Epub 2021 Apr 28.

The impact of plasma 25-hydroxyvitamin D on pulmonary function and exercise physiology in cystic fibrosis: A multicentre retrospective study.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

Raquel Revuelta Iniesta, Adam J Causer, Irantzu Arregui-Fresneda, Gary Connett, Mark I Allenby, Thomas Daniels, Mary P Carroll, Don S Urquhart, Zoe L Saynor

Affiliations

  1. School of Sport and Health Sciences, University of Exeter, Exeter, UK.
  2. Child Life and Health, University of Edinburgh, Edinburgh, UK.
  3. Department for Health, University of Bath, Bath, UK.
  4. Wessex Cystic Fibrosis Unit, University Hospital Southampton Foundation NHS Trust, Southampton, UK.
  5. National Institute for Health Research, Southampton Biomedical Research Centre, Southampton Children's Hospital, Southampton, UK.
  6. Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Sick Children, Edinburgh, UK.
  7. School of Sport, Health and Exercise Sciences, University of Portsmouth, Portsmouth, UK.

PMID: 33908093 DOI: 10.1111/jhn.12906

Abstract

BACKGROUND: A 25-hydroxyvitamin D (25OHD) may exert immunomodulatory effects on respiratory health, which may translate to improvements in exercise physiology. Thus, we aimed to investigate whether plasma 25OHD is associated with lung function and aerobic fitness in people with cystic fibrosis (pwCF).

METHODS: A multicentre retrospective review of pwCF (> 9 years old) attending the Royal Hospital for Sick Children (Edinburgh) or Wessex CF-Unit (Southampton) was performed between July 2017 and October 2019. Demographic and clinical data were collected. Plasma 25OHD measured closest in time to clinical cardiopulmonary exercise testing and/or spirometry [forced expiratory volume (FEV

RESULTS: Ninety pwCF [mean ± SD age: 19.1 ± 8.6 years, 54 (60%) children, 48 (53%) males and 88 (98%) Caucasian] were included. 25OHD deficiency and insufficiency was 15 (17%) and 44 (49%), respectively. 25OHD deficiency and insufficiency was significantly associated with pancreatic insufficiency (χ

CONCLUSIONS: We showed that 25OHD is associated with improved lung function and aerobic fitness in children and adolescents with CF. Mechanistic and high-quality prospective studies including both lung function and aerobic fitness as primary outcomes are now warranted.

© 2021 The British Dietetic Association Ltd.

Keywords: cardiopulmonary exercise testing; cystic fibrosis; lung function; ventilation; vitamin D

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