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Raesi A, Saedi Dezaki E, Moosapour H, et al. Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease. Iran J Pathol. 2020;16(2):144-153doi: 10.30699/IJP.2020.130491.2442.
Raesi, A., Saedi Dezaki, E., Moosapour, H., Saeidifard, F., Habibi, Z., Rahmani, F., Kheiri, S., & Taheri, E. (2021). Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease. Iranian journal of pathology, 16(2), 144-153. https://doi.org/10.30699/IJP.2020.130491.2442
Raesi, Ahmad, et al. "Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease." Iranian journal of pathology vol. 16,2 (2021): 144-153. doi: https://doi.org/10.30699/IJP.2020.130491.2442
Raesi A, Saedi Dezaki E, Moosapour H, Saeidifard F, Habibi Z, Rahmani F, Kheiri S, Taheri E. Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease. Iran J Pathol. 2021;16(2):144-153. doi: 10.30699/IJP.2020.130491.2442. Epub 2020 Oct 24. PMID: 33936225; PMCID: PMC8085287.
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Iran J Pathol. 2021;16(2):144-153. doi: 10.30699/IJP.2020.130491.2442. Epub 2020 Oct 24.

Hypocalcemia in Covid-19: A Prognostic Marker for Severe Disease.

Iranian journal of pathology

Ahmad Raesi, Ebrahim Saedi Dezaki, Hamideh Moosapour, Farzane Saeidifard, Zahra Habibi, Fereidoun Rahmani, Soleiman Kheiri, Elham Taheri

Affiliations

  1. Department of Internal Medicine, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  2. Department of Parasitology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  3. Evidence Based Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
  4. Department of Medicine, Northwell Health-Lenox Hill Hospital, Zucker School of Medicine at Hofstra/Northwell, New York, United States of America (USA).
  5. Division of Preventive Cardiology, Department of Cardiovascular Disease, Mayo Clinic, Rochester, United States of America (USA).
  6. Department of Infectious Disease, Clinical Research Development Unit, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  7. Department of Epidemiology and Biostatistics, School of Health, Modeling in Health Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran.
  8. Molecular Pathology and Cytogenetic Ward, Pathology Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

PMID: 33936225 PMCID: PMC8085287 DOI: 10.30699/IJP.2020.130491.2442

Abstract

BACKGROUND & OBJECTIVE: Previous studies have addressed the electrolyte abnormalities such as hypocalcemia in COVID-19 patients. We aimed to compare the laboratory findings especially the electrolyte levels among COVID-19 patients and healthy controls and evaluate their prognostic values.

METHODS: This case-control study included 91 COVID-19 patients and 169 healthy individuals. Their laboratory parameters including electrolytes, albumin, liver enzymes, complete blood count, vitamin D, and parathyroid hormone (PTH) were compared. We also analyzed the association between these markers and the major outcomes including severity, mortality and hospitalization.

RESULTS: Among patients with COVID-19, 59.3% of the patients had hypocalcemia on admission while in control group only 32.5% had low calcium level (OR=3.02, 95% CI: 1.79-5.13,

CONCLUSION: Patients with COVID-19 may present with considerable laboratory abnormalities including hypocalcemia. The hypocalcemia would be also associated with worse major clinical outcome and higher mortality risk.

Keywords: Albumin; COVID-19; Clinical severity; Electrolyte -imbalances; Hypocalcemia; Parathyroid hormone; Prognosis; Vitamin D

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