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Plastiras SC, Moutsopoulos HM. Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders. Arrhythm Electrophysiol Rev. 2021;10(1):17-25doi: 10.15420/aer.2020.43.
Plastiras, S. C., & Moutsopoulos, H. M. (2021). Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders. Arrhythmia & electrophysiology review, 10(1), 17-25. https://doi.org/10.15420/aer.2020.43
Plastiras, Sotiris C, and Moutsopoulos, Haralampos M. "Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders." Arrhythmia & electrophysiology review vol. 10,1 (2021): 17-25. doi: https://doi.org/10.15420/aer.2020.43
Plastiras SC, Moutsopoulos HM. Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders. Arrhythm Electrophysiol Rev. 2021 Apr;10(1):17-25. doi: 10.15420/aer.2020.43. PMID: 33936739; PMCID: PMC8076972.
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Arrhythm Electrophysiol Rev. 2021 Apr;10(1):17-25. doi: 10.15420/aer.2020.43.

Arrhythmias and Conduction Disturbances in Autoimmune Rheumatic Disorders.

Arrhythmia & electrophysiology review

Sotiris C Plastiras, Haralampos M Moutsopoulos

Affiliations

  1. Echocardiography Unit, Bioiatriki SA, Bioiatriki Healthcare Group, Athens, Greece.
  2. Medical Sciences/Immunology, Academy of Athens, Athens, Greece.

PMID: 33936739 PMCID: PMC8076972 DOI: 10.15420/aer.2020.43

Abstract

Rhythm and conduction disturbances and sudden cardiac death are important manifestations of cardiac involvement in autoimmune rheumatic diseases (ARD), which have a serious impact on morbidity and mortality. While the underlying arrhythmogenic mechanisms are multifactorial, myocardial fibrosis plays a pivotal role. It accounts for a substantial portion of cardiac mortality and may manifest as atrial and ventricular arrhythmias, conduction system abnormalities, biventricular cardiac failure or sudden death. In patients with ARD, myocardial fibrosis is considered to be the hallmark of cardiac involvement as a result of inflammatory process or to coronary artery occlusive disease. Myocardial fibrosis constitutes the pathological substrates for reentrant circuits. The presence of supraventricular extra systoles, tachyarrhythmias, ventricular activity and conduction disturbances are not uncommon in patients with ARDs, more often in systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, inflammatory muscle disorders and anti-neutrophil cytoplasm antibody-associated vasculitis. In this review, the type, the relative prevalence and the underlying mechanisms of rhythm and conduction disturbances in the emerging field of cardiorheumatology are provided.

Copyright © 2021, Radcliffe Cardiology.

Keywords: Autoimmune systemic disorders; arrhythmias; conduction disturbances; heart involvement

Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

References

  1. Arthritis Rheum. 2009 Apr;60(4):1187-92 - PubMed
  2. Semin Arthritis Rheum. 2009 Dec;39(3):145-56 - PubMed
  3. Ann Rheum Dis. 2005 May;64(5):753-9 - PubMed
  4. Arrhythm Electrophysiol Rev. 2019 Mar;8(1):47-53 - PubMed
  5. Arthritis Rheum. 2004 Apr;50(4):1248-52 - PubMed
  6. J Rheumatol. 1992 Jun;19(6):1004-5 - PubMed
  7. QJM. 2005 Feb;98(2):97-111 - PubMed
  8. Ann Intern Med. 1981 Jan;94(1):38-40 - PubMed
  9. Arrhythm Electrophysiol Rev. 2016 Aug;5(2):130-5 - PubMed
  10. Hellenic J Cardiol. 2017 Mar - Apr;58(2):159-160 - PubMed
  11. J Clin Rheumatol. 1997 Aug;3(4):203-10 - PubMed
  12. Cardiol Rev. 2019 May/Jun;27(3):131-137 - PubMed
  13. Ann Rheum Dis. 2010 Oct;69(10):1809-15 - PubMed
  14. Circulation. 2003 Mar 11;107(9):1303-7 - PubMed
  15. Clin Cardiol. 1993 Nov;16(11):802-8 - PubMed
  16. Expert Rev Clin Immunol. 2018 Dec;14(12):1043-1053 - PubMed
  17. Arthritis Rheum. 2001 Mar;44(3):666-75 - PubMed
  18. Circulation. 2009 Apr 14;119(14):1853-66 - PubMed
  19. Clin Exp Rheumatol. 1996 Jul-Aug;14(4):373-9 - PubMed
  20. Heart Rhythm. 2015 Jun;12(6):e41-63 - PubMed
  21. Medicine (Baltimore). 1977 Jul;56(4):255-86 - PubMed
  22. Europace. 2017 Mar 1;19(3):465-511 - PubMed
  23. J Rheumatol. 1997 Mar;24(3):445-51 - PubMed
  24. Circulation. 1976 Mar;53(3):483-90 - PubMed
  25. Rheumatol Int. 1999;18(5-6):163-9 - PubMed
  26. Eur Heart J. 1995 Jun;16(6):848-51 - PubMed
  27. Arrhythm Electrophysiol Rev. 2014 Aug;3(2):113-5 - PubMed
  28. Semin Arthritis Rheum. 2007 Jun;36(6):392-6 - PubMed
  29. Int J Rheum Dis. 2012 Apr;15(2):e26-7 - PubMed
  30. Europace. 2012 Nov;14(11):1545-52 - PubMed
  31. Curr Opin Rheumatol. 2011 Nov;23(6):545-54 - PubMed
  32. Clin Cardiol. 1993 Mar;16(3):260-4 - PubMed
  33. J Am Coll Cardiol. 2018 Dec 18;72(24):3158-3176 - PubMed
  34. Rheumatol Int. 2013 Apr;33(4):1093-6 - PubMed
  35. Circulation. 2001 Mar 20;103(11):1599-604 - PubMed
  36. J Rheumatol. 1995 Jul;22(7):1265-70 - PubMed
  37. J Autoimmun. 2018 Aug;92:87-92 - PubMed
  38. Ann Intern Med. 1981 Jan;94(1):41-3 - PubMed
  39. J Am Coll Cardiol. 2007 Nov 20;50(21):2021-8 - PubMed
  40. Semin Arthritis Rheum. 1987 Nov;17(2):126-41 - PubMed
  41. Lupus. 2005;14(9):708-12 - PubMed
  42. Angiology. 2003 Nov-Dec;54(6):729-31 - PubMed
  43. Clin Exp Rheumatol. 2006 Nov-Dec;24(6):683-9 - PubMed
  44. Circ J. 2020 Apr 24;84(5):685-694 - PubMed
  45. Arch Intern Med. 1984 Nov;144(11):2185-9 - PubMed
  46. Ann Rheum Dis. 1983 Aug;42(4):389-97 - PubMed
  47. Expert Opin Pharmacother. 2015;16(17):2637-51 - PubMed
  48. Europace. 2004 Jul;6(4):336-42 - PubMed
  49. Europace. 2015 Nov;17(11):1601-87 - PubMed
  50. Autoimmun Rev. 2006 May;5(5):306-13 - PubMed
  51. J Autoimmun. 2017 Aug;82:1-12 - PubMed
  52. Rheumatology (Oxford). 2006 Oct;45 Suppl 4:iv39-42 - PubMed
  53. Rheumatology (Oxford). 2020 Aug 1;59(8):1938-1948 - PubMed
  54. Medicine (Baltimore). 1971 Mar;50(2):85-95 - PubMed
  55. Semin Arthritis Rheum. 1989 Dec;19(3):191-200 - PubMed
  56. BMJ. 2011 Jul 04;343:d3450 - PubMed
  57. Autoimmun Rev. 2014 Apr-May;13(4-5):331-46 - PubMed
  58. Eur Heart J. 2005 Oct;26(20):2083-92 - PubMed
  59. Am J Med. 2008 Oct;121(10 Suppl 1):S9-14 - PubMed
  60. Rheum Dis Clin North Am. 2014 Feb;40(1):11-26 - PubMed
  61. Arthritis Care Res (Hoboken). 2011 Jul;63(7):1031-7 - PubMed
  62. Am Heart J. 1993 Jan;125(1):194-203 - PubMed
  63. Eur Heart J. 2017 Jun 7;38(22):1717-1727 - PubMed
  64. J Am Coll Cardiol. 2007 Apr 17;49(15):1642-1648 - PubMed
  65. Am J Med. 1988 Jun;84(6):1007-15 - PubMed
  66. Arthritis Care Res (Hoboken). 2015 Jan;67(1):128-35 - PubMed
  67. Ann Intern Med. 1965 Sep;63:402-10 - PubMed
  68. Ann Rheum Dis. 2017 Nov;76(11):1897-1905 - PubMed
  69. Lancet. 2013 Aug 31;382(9894):819-31 - PubMed
  70. Rev Bras Reumatol. 2010 Jan-Feb;50(1):81-9 - PubMed
  71. Eur Heart J. 2001 May;22(10):813-24 - PubMed
  72. Arrhythm Electrophysiol Rev. 2014 Aug;3(2):107-12 - PubMed
  73. Rheum Dis Clin North Am. 2014 Feb;40(1):51-60 - PubMed
  74. J Am Coll Cardiol. 2010 May 25;55(21):2293-8 - PubMed
  75. J Interv Card Electrophysiol. 2012 Mar;33(2):171-257 - PubMed
  76. BMJ. 2018 Apr 23;361:k1036 - PubMed
  77. Arrhythm Electrophysiol Rev. 2012 Sep;1(1):29-33 - PubMed
  78. Lupus. 2005;14(10):846-52 - PubMed
  79. Heart. 2002 Nov;88(5):443 - PubMed
  80. Ann Rheum Dis. 2010 Jan;69(1):218-21 - PubMed
  81. Arthritis Rheum. 1999 Mar;42(3):421-30 - PubMed
  82. Clin Rev Allergy Immunol. 2009 Jun;36(2-3):176-200 - PubMed
  83. Am Heart J. 1964 Jul;68:119-30 - PubMed
  84. Q J Med. 1992 Feb;82(298):139-48 - PubMed
  85. Heart Rhythm. 2011 Nov;8(11):1788-95 - PubMed
  86. Arthritis Rheum. 2007 Nov;56(11):3827-36 - PubMed
  87. Eur Heart J. 2007 Aug;28(15):1797-804 - PubMed
  88. J Cardiol Cases. 2017 Jul 18;16(4):134-137 - PubMed
  89. J Rheumatol. 2008 Oct;35(10):1958-65 - PubMed
  90. Ann Noninvasive Electrocardiol. 2009 Jul;14(3):251-7 - PubMed
  91. Curr Opin Rheumatol. 2009 Jan;21(1):29-34 - PubMed
  92. Circulation. 2012 Feb 21;125(7):967-9 - PubMed
  93. Arthritis Rheum. 1985 Nov;28(11):1259-66 - PubMed
  94. Heart Rhythm. 2018 Oct;15(10):e190-e252 - PubMed
  95. Scand J Rheumatol. 2012 Feb;41(1):33-8 - PubMed
  96. Rheumatol Int. 2018 Sep;38(9):1615-1621 - PubMed
  97. Clin Cardiol. 2012 Nov;35(11):686-91 - PubMed
  98. J Electrocardiol. 1996 Jan;29(1):17-25 - PubMed
  99. Semin Arthritis Rheum. 2000 Aug;30(1):1-16 - PubMed
  100. Am J Med. 1976 Sep;61(3):361-6 - PubMed
  101. Rheumatol Int. 2007 Jul;27(9):813-8 - PubMed
  102. J Rheumatol. 1994 Oct;21(10):1845-8 - PubMed

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