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Molloy SF, Ross B, Kanyama C, et al. Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. Open Forum Infect Dis. 2021;8(4):ofab066doi: 10.1093/ofid/ofab066.
Molloy, S. F., Ross, B., Kanyama, C., Mfinanga, S., Lesikari, S., Heyderman, R. S., Kalata, N., Ellis, J., Kouanfack, C., Chanda, D., Temfack, E., Lakhi, S., Moodley, A., Chan, A. K., van Oosterhout, J. J., Mapoure, Y., Mwaba, P., Lalloo, D. G., Wang, D., Lortholary, O., Jaffar, S., Hosseinipour, M. C., Loyse, A., Harrison, T. S., & Bicanic, T. (2021). Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. Open forum infectious diseases, 8(4), ofab066. https://doi.org/10.1093/ofid/ofab066
Molloy, Síle F, et al. "Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis." Open forum infectious diseases vol. 8,4 (2021): ofab066. doi: https://doi.org/10.1093/ofid/ofab066
Molloy SF, Ross B, Kanyama C, Mfinanga S, Lesikari S, Heyderman RS, Kalata N, Ellis J, Kouanfack C, Chanda D, Temfack E, Lakhi S, Moodley A, Chan AK, van Oosterhout JJ, Mapoure Y, Mwaba P, Lalloo DG, Wang D, Lortholary O, Jaffar S, Hosseinipour MC, Loyse A, Harrison TS, Bicanic T. Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis. Open Forum Infect Dis. 2021 Feb 05;8(4):ofab066. doi: 10.1093/ofid/ofab066. eCollection 2021 Apr. PMID: 33937434; PMCID: PMC8078267.
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Open Forum Infect Dis. 2021 Feb 05;8(4):ofab066. doi: 10.1093/ofid/ofab066. eCollection 2021 Apr.

Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis.

Open forum infectious diseases

Síle F Molloy, Brad Ross, Cecilia Kanyama, Sayoki Mfinanga, Sokoine Lesikari, Robert S Heyderman, Newton Kalata, Jayne Ellis, Charles Kouanfack, Duncan Chanda, Elvis Temfack, Shabir Lakhi, Anand Moodley, Adrienne K Chan, Joep J van Oosterhout, Yacouba Mapoure, Peter Mwaba, David G Lalloo, Duolao Wang, Olivier Lortholary, Shabbar Jaffar, Mina C Hosseinipour, Angela Loyse, Thomas S Harrison, Tihana Bicanic

Affiliations

  1. Centre for Global Health, Institute of Infection and Immunity, St George's University of London, London, United Kingdom.
  2. Clinical Academic Group in Infection, St George's University Hospital, LondonUnited Kingdom.
  3. UNC Project, Kamuzu Central Hospital, Lilongwe, Malawi.
  4. National Institute for Medical Research, Muhimbili Centre, Dar es Salaam, Tanzania.
  5. Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
  6. University College London, London, United Kingdom.
  7. Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
  8. College of Medicine, Queen Elizabeth Hospital, Blantyre, Malawi.
  9. The Hospital for Tropical Diseases, University College Hospital, LondonUnited Kingdom.
  10. H?pital Central Yaoundé/Site ANRS Cameroun, Yaoundé, Cameroon.
  11. Institute for Medical Research and Training, University Teaching Hospital, Lusaka, Zambia.
  12. Douala General Hospital, Douala, Cameroon.
  13. National Public Health Laboratory, Yaounde, Cameroon.
  14. University Teaching Hospital, Lusaka, Zambia.
  15. Department of Neurology, University of the Free State, Bloemfontein, South Africa.
  16. Dignitas International, Zomba Central Hospital, Zomba, Malawi.
  17. Division of Infectious Diseases, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada.
  18. Partners in Hope, LilongweMalawi.
  19. David Geffen School of Medicine, University of California, Los Angeles, USA.
  20. Department of Internal Medicine and Directorate of Research and Post Graduate Studies, Lusaka Apex Medical University, Lusaka, Zambia.
  21. Institut Pasteur, Molecular Mycology Unit, Centre National de la Recherche Scientifique, Paris, France.
  22. Paris Descartes University, Necker Pasteur Center for Infectious Diseases and Tropical Medicine, Institut Imagine, Assistance Publique - Hôpitaux de Paris, Paris, France.
  23. University of North Carolina, Chapel Hill, North Carolina, USA.

PMID: 33937434 PMCID: PMC8078267 DOI: 10.1093/ofid/ofab066

Abstract

Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors and remained severely impaired. Baseline cerebrospinal fluid opening pressure ≥40 cmH

© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

Keywords: HIV; cryptococcal meningitis; fungal burden; raised intracranial pressure; visual loss

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