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Nambiyar K, Gupta K, Debi U, et al. ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature. Autops Case Rep. 2021;11:e2020231doi: 10.4322/acr.2020.231.
Nambiyar, K., Gupta, K., Debi, U., Sinha, S. K., & Kochhar, R. (2021). ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature. Autopsy & case reports, 11e2020231. https://doi.org/10.4322/acr.2020.231
Nambiyar, Kaniyappan, et al. "ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature." Autopsy & case reports vol. 11 (2021): e2020231. doi: https://doi.org/10.4322/acr.2020.231
Nambiyar K, Gupta K, Debi U, Sinha SK, Kochhar R. ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature. Autops Case Rep. 2021 Jan 28;11:e2020231. doi: 10.4322/acr.2020.231. PMID: 33968818; PMCID: PMC8020592.
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Autops Case Rep. 2021 Jan 28;11:e2020231. doi: 10.4322/acr.2020.231.

ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature.

Autopsy & case reports

Kaniyappan Nambiyar, Kirti Gupta, Uma Debi, Saroj Kant Sinha, Rakesh Kochhar

Affiliations

  1. Postgraduate Institute of Medical Education and Research, Department of Histopathology, Chandigarh, India.
  2. Postgraduate Institute of Medical Education and Research, Department of Radiodiagnosis and imaging, Chandigarh, India.
  3. Postgraduate Institute of Medical Education and Research, Department of Gastroenterology, Chandigarh, India.

PMID: 33968818 PMCID: PMC8020592 DOI: 10.4322/acr.2020.231

Abstract

Cardiac lymphoma is a rare entity. In this setting, the secondary involvement of the heart is far more frequent than the primary cardiac lymphoma. Herein, we present an autopsy case of a disseminated anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma with a dominant mediastinal involvement. Extensive cardiac infiltration with the near replacement of the myocardial wall by the neoplastic cells was observed. A total of nine isolated case reports of anaplastic large cell lymphoma with cardiac involvement were found in the English-language literature, and a widespread cardiac and thymic infiltration by the systemic ALK-positive anaplastic large cell lymphoma has not been documented. An incidental regenerative nodule was also identified in the liver. The patient died of pulmonary thromboembolism and cardiac arrest.

Copyright: © 2020 The Authors.

Keywords: Anaplastic lymphoma kinase; Heart; Lymphoma, Large-cell, Anaplastic; Thromboembolism; Thymus Gland

Conflict of interest statement

Conflict of interest: None.

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