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Shapouri-Moghaddam A, Tavakkol Afshari SJ, Rahimi HR, et al. Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series. Rep Biochem Mol Biol. 2021;9(4):379-384doi: 10.52547/rbmb.9.4.373.
Shapouri-Moghaddam, A., Tavakkol Afshari, S. J., Rahimi, H. R., Saeed Modaghegh, M. H., Mahmoudi, M., & Ehteshamfar, S. M. (2021). Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series. Reports of biochemistry & molecular biology, 9(4), 379-384. https://doi.org/10.52547/rbmb.9.4.373
Shapouri-Moghaddam, Abbas, et al. "Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series." Reports of biochemistry & molecular biology vol. 9,4 (2021): 379-384. doi: https://doi.org/10.52547/rbmb.9.4.373
Shapouri-Moghaddam A, Tavakkol Afshari SJ, Rahimi HR, Saeed Modaghegh MH, Mahmoudi M, Ehteshamfar SM. Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series. Rep Biochem Mol Biol. 2021 Jan;9(4):379-384. doi: 10.52547/rbmb.9.4.373. PMID: 33969130; PMCID: PMC8068440.
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Rep Biochem Mol Biol. 2021 Jan;9(4):379-384. doi: 10.52547/rbmb.9.4.373.

Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series.

Reports of biochemistry & molecular biology

Abbas Shapouri-Moghaddam, Seyed Jalil Tavakkol Afshari, Hamid Reza Rahimi, Mohammad-Hadi Saeed Modaghegh, Mahmoud Mahmoudi, Seyed Morteza Ehteshamfar

Affiliations

  1. Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Vascular and Endovascular Surgery Research Center, Alavi Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 33969130 PMCID: PMC8068440 DOI: 10.52547/rbmb.9.4.373

Abstract

BACKGROUND: Autoimmunity causes the loss of normal immune homeostasis and involves the presence of autoantibodies and inflammation. Thromboangiitis obliterans or Buerger's disease (BD) refers to a type of vascular obstructive syndrome, with tobacco exposure accounting for disease formation and progression. However, the current understanding of autoimmunity is unclear in the context of BD, and the scientific findings are not enough to support autoimmune mechanisms. This study was aimed at investigating autoimmunity factors in patients with BD.

METHODS: Clinical and experimental examinations were performed on 80 patients with BD. The diagnostic work-up for autoimmunity was composed of IgM rheumatoid factor (RF), anti-nuclear antibodies (ANA), The erythrocyte sedimentation rate (ESR), anti-cyclic citrullinated peptide (CCP) antibodies, Antiphospholipid antibodies (APA), Anti-cardiolipin antibodies (ACLA), anti-double-stranded DNA (ds-DNA), and extractable nuclear antigen (ENA) profile. Immunomarkers were detected using the quantitative enzyme-linked immunosorbent assay (ELISA).

RESULTS: Raynaud's phenomenon (84.93%), cold sensitivity (76.25%), and claudication (73.75%) were the most common symptoms in the BD patients. Also, 64.29% represented with high ANA levels and positive RF, while 42.11% were found with increased ANA and ESR levels. The ANA/RF positive BD patients had ESR> 15 mm/hr and a high prevalence of cold sensitivity, claudication, and Raynaud's phenomenon (p> 0.05).

CONCLUSION: There is a possibility of a non-specific autoimmune disposition among BD patients. RF and ANA could be considered for predicting disease progression.

Keywords: Antibodies; Autoimmunity; Buerger's Disease; Immune System

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