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Roughan WH, Campos AI, García-Marín LM, et al. Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness. Front Psychiatry. 2021;12:643609doi: 10.3389/fpsyt.2021.643609.
Roughan, W. H., Campos, A. I., García-Marín, L. M., Cuéllar-Partida, G., Lupton, M. K., Hickie, I. B., Medland, S. E., Wray, N. R., Byrne, E. M., Ngo, T. T., Martin, N. G., & Rentería, M. E. (2021). Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness. Frontiers in psychiatry, 12643609. https://doi.org/10.3389/fpsyt.2021.643609
Roughan, William H, et al. "Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness." Frontiers in psychiatry vol. 12 (2021): 643609. doi: https://doi.org/10.3389/fpsyt.2021.643609
Roughan WH, Campos AI, García-Marín LM, Cuéllar-Partida G, Lupton MK, Hickie IB, Medland SE, Wray NR, Byrne EM, Ngo TT, Martin NG, Rentería ME. Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness. Front Psychiatry. 2021 Apr 12;12:643609. doi: 10.3389/fpsyt.2021.643609. eCollection 2021. PMID: 33912086; PMCID: PMC8072020.
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Front Psychiatry. 2021 Apr 12;12:643609. doi: 10.3389/fpsyt.2021.643609. eCollection 2021.

Comorbid Chronic Pain and Depression: Shared Risk Factors and Differential Antidepressant Effectiveness.

Frontiers in psychiatry

William H Roughan, Adrián I Campos, Luis M García-Marín, Gabriel Cuéllar-Partida, Michelle K Lupton, Ian B Hickie, Sarah E Medland, Naomi R Wray, Enda M Byrne, Trung Thanh Ngo, Nicholas G Martin, Miguel E Rentería

Affiliations

  1. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
  2. Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
  3. UQ Diamantina Institute, The University of Queensland and Translational Research Institute, Brisbane, QLD, Australia.
  4. Brain and Mind Centre, University of Sydney, Camperdown, NSW, Australia.
  5. Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.
  6. Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.

PMID: 33912086 PMCID: PMC8072020 DOI: 10.3389/fpsyt.2021.643609

Abstract

The bidirectional relationship between depression and chronic pain is well-recognized, but their clinical management remains challenging. Here we characterize the shared risk factors and outcomes for their comorbidity in the Australian Genetics of Depression cohort study (

Copyright © 2021 Roughan, Campos, García-Marín, Cuéllar-Partida, Lupton, Hickie, Medland, Wray, Byrne, Ngo, Martin and Rentería.

Keywords: antidepressant; chronic pain; comorbidity; depression; suicide; treatment response

Conflict of interest statement

IH has been Commissioner of Australia's National Mental Health Commission (2012–2018); Co-director of Health and Policy at the Brain and Mind Centre, University of Sydney; leading community-based and

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