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Christenson E, Stout MJ, Williams D, et al. Prenatal Low-Dose Aspirin Use Associated with Reduced Incidence of Postpartum Hypertension among Women with Preeclampsia. Am J Perinatol. 2021;doi: 10.1055/s-0041-1728826.
Christenson, E., Stout, M. J., Williams, D., Verma, A. K., Davila-Roman, V. G., & Lindley, K. J. (2021). Prenatal Low-Dose Aspirin Use Associated with Reduced Incidence of Postpartum Hypertension among Women with Preeclampsia. American journal of perinatology, . https://doi.org/10.1055/s-0041-1728826
Christenson, Eleanor, et al. "Prenatal Low-Dose Aspirin Use Associated with Reduced Incidence of Postpartum Hypertension among Women with Preeclampsia." American journal of perinatology vol. (2021). doi: https://doi.org/10.1055/s-0041-1728826
Christenson E, Stout MJ, Williams D, Verma AK, Davila-Roman VG, Lindley KJ. Prenatal Low-Dose Aspirin Use Associated with Reduced Incidence of Postpartum Hypertension among Women with Preeclampsia. Am J Perinatol. 2021 May 03; doi: 10.1055/s-0041-1728826. Epub 2021 May 03. PMID: 33940641.
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Am J Perinatol. 2021 May 03; doi: 10.1055/s-0041-1728826. Epub 2021 May 03.

Prenatal Low-Dose Aspirin Use Associated with Reduced Incidence of Postpartum Hypertension among Women with Preeclampsia.

American journal of perinatology

Eleanor Christenson, Molly J Stout, Dominique Williams, Amanda K Verma, Victor G Davila-Roman, Kathryn J Lindley

Affiliations

  1. Internal Medicine Resident, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.
  2. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan.
  3. Division of Medicine, Cardiovascular, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.
  4. Division of Medicine, Obstetrics and Gynecology, Cardiovascular, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri.

PMID: 33940641 DOI: 10.1055/s-0041-1728826

Abstract

OBJECTIVE:  Postpartum hypertension (PP-HTN), defined as systolic/diastolic blood pressure (SBP/DBP) ≥140/90, on two occasions at least 4 hours apart after delivery occurs in up to 50% of preeclamptic pregnancies, and is associated with adverse maternal outcomes. Excessive production of antiangiogenic factors (i.e., soluble fms-like tyrosine kinase 1 [sFLT1]) and reduced levels of proangiogenic factors (i.e., placental growth factor [PlGF]) are associated with preeclamptic pregnancies. The aim of this study was to identify clinical risk factors and/or serum biomarkers associated with PP-HTN in preeclampsia.

STUDY DESIGN:  Preeclamptic women (

RESULTS:  Baseline comorbidities and antihypertensive use were similar among those who developed PP-HTN and those who did not. Among preeclamptic patients, 33% developed PP-HTN; these had significantly more severe preeclampsia features versus no PP-HTN (96 vs. 78%,

CONCLUSION:  One-third of women with preeclampsia develop PP-HTN; these patients have more severe preeclampsia and have higher re-hospitalization rates. Prenatal low-dose ASA use was associated with significantly lower incidence of PP-HTN, reduced levels of antiangiogenic factors, and lower 6-week re-hospitalization rates. These findings, if replicated, may have clinical implications on the use of low-dose ASA during pregnancy to reduce incidence of postpartum HTN.

KEY POINTS: · Postpartum hypertension is common in preeclampsia.. · Prenatal aspirin may reduce postpartum hypertension.. · Prenatal aspirin may reduce sFLT1 levels..

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Conflict of interest statement

None declared.

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