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Koren Y, Lubetzky R, Mandel D, et al. Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study. Am J Perinatol. 2021;doi: 10.1055/s-0041-1729556.
Koren, Y., Lubetzky, R., Mandel, D., Ovental, A., Deutsch, V., Hadanny, A., & Moran-Lev, H. (2021). Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study. American journal of perinatology, . https://doi.org/10.1055/s-0041-1729556
Koren, Yael, et al. "Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study." American journal of perinatology vol. (2021). doi: https://doi.org/10.1055/s-0041-1729556
Koren Y, Lubetzky R, Mandel D, Ovental A, Deutsch V, Hadanny A, Moran-Lev H. Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study. Am J Perinatol. 2021 May 03; doi: 10.1055/s-0041-1729556. Epub 2021 May 03. PMID: 33940646.
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Am J Perinatol. 2021 May 03; doi: 10.1055/s-0041-1729556. Epub 2021 May 03.

Anemia, Hepcidin, and Vitamin D in Healthy Preterm Infants: A Pilot Study.

American journal of perinatology

Yael Koren, Ronit Lubetzky, Dror Mandel, Amit Ovental, Varda Deutsch, Amir Hadanny, Hadar Moran-Lev

Affiliations

  1. Department of Neonatology, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  2. Department of Pediatrics, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  3. Hematology Laboratories, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  4. The Mina and Everard Goodman Faculty of Life Science, Bar Ilan University, Ramat Gan, Israel.
  5. Department of Pediatric Gastroenterology, Dana Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

PMID: 33940646 DOI: 10.1055/s-0041-1729556

Abstract

OBJECTIVE:  The etiology of anemia in premature neonates is multifactorial and may involve anemia of inflammation mediated by hepcidin. Hepcidin expression is suppressed by vitamin D. We aimed to investigate the interrelationship between hepcidin, anemia, and vitamin D status in preterm infants.

STUDY DESIGN:  Preterm infants aged 1 to 5 weeks were prospectively recruited at the neonatal intensive care unit of the Dana Dwek Children Hospital. Blood counts and serum levels of hepcidin, ferritin, iron, 25-hydroxyvitamin D [25(OH)D] and C-reactive protein (CRP) were measured and compared between anemic and nonanemic preterm infants.

RESULTS:  Forty-seven preterm infants (mean ± standard deviation gestational age at birth 32.8 ± 1.1 weeks, 66% males) were recruited. In total, 36% of the preterm infants were vitamin D deficient [25(OH)D < 20 ng/mL] and 15% were anemic. Hepcidin levels were significantly higher in anemic premature infants than in the nonanemic group (55.3 ± 23.9 ng/mL vs. 30.1 ± 16.3 ng/mL, respectively,

CONCLUSION:  Anemia of prematurity was associated with high hepcidin serum levels. The exact mechanisms leading to anemia and the role of vitamin D warrant further investigation.

KEY POINTS: · Hepcidin levels were significantly higher in anemic premature infants.. · A positive correlation was found between hepcidin and ferritin.. · Negative correlation was found between 25(OH)D and CRP..

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Conflict of interest statement

None declared.

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