Display options
Cite
Toft H, Bramness J, Tilden T, et al. Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment. Acta Neuropsychiatr. 2021;33(5):254-260doi: 10.1017/neu.2021.11.
Toft, H., Bramness, J., Tilden, T., Bolstad, I., & Lien, L. (2021). Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment. Acta neuropsychiatrica, 33(5), 254-260. https://doi.org/10.1017/neu.2021.11
Toft, Helge, et al. "Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment." Acta neuropsychiatrica vol. 33,5 (2021): 254-260. doi: https://doi.org/10.1017/neu.2021.11
Toft H, Bramness J, Tilden T, Bolstad I, Lien L. Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment. Acta Neuropsychiatr. 2021 Oct;33(5):254-260. doi: 10.1017/neu.2021.11. Epub 2021 Apr 27. PMID: 33902770.
Copy Download .nbib Format: NLM
Share it on

Acta Neuropsychiatr. 2021 Oct;33(5):254-260. doi: 10.1017/neu.2021.11. Epub 2021 Apr 27.

Persistent level of mental distress in PTSD patients is not reflected in cytokine levels 1 year after the treatment.

Acta neuropsychiatrica

Helge Toft, Jørgen Bramness, Terje Tilden, Ingeborg Bolstad, Lars Lien

Affiliations

  1. Department of Mental Health, Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway.
  2. Department of Alcohol, Tobacco and Drugs, Institute of Public Health, Oslo, Norway.
  3. Faculty of Health Sciences, Institute of Clinical Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
  4. Research Institute, Modum Bad Psychiatric Center, Vikersund, Norway.
  5. Faculty of Social and Health Sciences, Department of Health and Nursing Sciences, Inland Norway University of Applied Sciences, Elverum, Norway.

PMID: 33902770 DOI: 10.1017/neu.2021.11

Abstract

OBJECTIVE: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient treatment.

METHODS: Patients in treatment for serious non-psychotic mental disorders were recruited at the beginning of their treatment stay at a psychiatric centre in Norway. Ninety patients submitted serum samples and filled out the Hopkins Symptom Checklist-90 Revised Global Severity Index (HSCL-90R GSI) questionnaire during their mainstay and at a follow-up stay 1 year after discharge. Of these patients, 33 were diagnosed with PTSD, 48 with anxiety, depression, or eating disorder, while 9 patients had missing data. The patients were diagnosed using the Mini-International Neuropsychiatric Interview (MINI).

RESULTS: At the follow-up stay (T3), PTSD patients had higher levels of GSI scores than non-PTSD patients (p = 0.048). These levels were unchanged from the year before (T2) in both groups. The levels of circulating cytokines/chemokine did not differ between the PTSD and non-PTSD patients at T3. At T2, however, the PTSD and non-PTSD groups exhibited different levels of interleukin 1β (IL-1β) (p = 0.053), IL-1RA (p = 0.042), and TNF-α (p = 0.037), with the PTSD patients having the higher levels.

CONCLUSION: Despite exhibiting different mental distress scores, the PTSD and non-PTSD patients did not differ regarding levels of circulating inflammatory markers at 1-year follow-up.

Keywords: Cytokines; depression; inflammation; post-traumatic stress disorders

Publication Types