Clin Epidemiol Glob Health. 2021 Jul-Sep;11:100770. doi: 10.1016/j.cegh.2021.100770. Epub 2021 May 08.
Hematological profile and biochemical markers of COVID-19 non-survivors: A retrospective analysis.
Clinical epidemiology and global health
Mukesh Bairwa, Rajesh Kumar, Kalpana Beniwal, Deepjyoti Kalita, Yogesh Bahurupi
Affiliations
Affiliations
- Department of Internal Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
- Department of Nursing, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
- Department of Microbiology, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
- Department of Community & Family Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India.
PMID: 33997479
PMCID: PMC8106521 DOI: 10.1016/j.cegh.2021.100770
Abstract
BACKGROUND: Coronavirus disease is primarily transmitted through the respiratory route and bodily contact. The fatality in COVID-19 cases was alarming in the initial days. This study analyzes hematological and biochemical markers of COVID-19 non-survivors
MATERIAL AND METHODS: In this single-center study, records of 249 patients hospitalized with COVID-19 were studied for hematological profile and biochemical markers. Records of patients with laboratory-confirmed COVID-19 disease hospitalized between April 14, 2020, to August 15, 2020, were included in the analysis.
RESULTS: Significantly, the disease mortality was associated with increased procalcitonin (
CONCLUSIONS: The clinicians may consider the hematological and biochemical parameters in the patients with COVID-19 in future decision-making. These indicators might support clinical decisions to identify high fatality cases and poor diagnosis in the initial admission phase. In COVID-19 patients, we recommend close monitoring on procalcitonin, C-reactive protein, neutrophils count, and white blood cell count as a clinical indicator for potential progression to critical illness.
© 2021 The Author(s).
Keywords: Biomarkers; C-Reactive protein; COVID-19; Critical illness; l-lactate dehydrogenase
Conflict of interest statement
No potential conflict of interest relevant to this article was reported.
References
- N Engl J Med. 2020 Mar 26;382(13):1199-1207 - PubMed
- J Am Geriatr Soc. 2020 May;68(5):926-929 - PubMed
- Clin Infect Dis. 2020 Jul 28;71(15):762-768 - PubMed
- Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67 - PubMed
- Clin Exp Med. 2021 Feb;21(1):35-39 - PubMed
- J Educ Health Promot. 2021 Feb 27;10:44 - PubMed
- Open Forum Infect Dis. 2020 Apr 29;7(5):ofaa152 - PubMed
- Eur J Intern Med. 2020 Jun;76:97-99 - PubMed
- Infect Chemother. 2020 Jun;52(2):154-164 - PubMed
- BMC Infect Dis. 2020 Jul 16;20(1):519 - PubMed
- EBioMedicine. 2020 May;55:102763 - PubMed
- Emerg Infect Dis. 2004 Feb;10(2):311-6 - PubMed
- Obesity (Silver Spring). 2020 May;28(5):848 - PubMed
- Intensive Care Med. 2015 Oct;41(10):1739-51 - PubMed
- JAMA. 2020 Mar 17;323(11):1061-1069 - PubMed
- Sci Rep. 2020 Oct 2;10(1):16384 - PubMed
- JAMA Intern Med. 2020 Aug 1;180(8):1081-1089 - PubMed
- EClinicalMedicine. 2020 Jul 03;24:100426 - PubMed
- Front Immunol. 2019 Jul 17;10:1687 - PubMed
Publication Types