Display options
Cite
van de Loo AJ, Raasveld SJ, Hogewoning A, et al. Immune Responses after Heavy Alcohol Consumption: Cytokine Concentrations in Hangover-Sensitive and Hangover-Resistant Drinkers. Healthcare (Basel). 2021;9(4)doi: 10.3390/healthcare9040395.
van de Loo, A. J., Raasveld, S. J., Hogewoning, A., Zeeuw, R., Bosma, E. R., Bouwmeester, N. H., Lukkes, M., Knipping, K., Mackus, M., Kraneveld, A. D., Brookhuis, K. A., Garssen, J., Scholey, A., & Verster, J. C. (2021). Immune Responses after Heavy Alcohol Consumption: Cytokine Concentrations in Hangover-Sensitive and Hangover-Resistant Drinkers. Healthcare (Basel, Switzerland), 9(4), . https://doi.org/10.3390/healthcare9040395
van de Loo, Aurora Jae, et al. "Immune Responses after Heavy Alcohol Consumption: Cytokine Concentrations in Hangover-Sensitive and Hangover-Resistant Drinkers." Healthcare (Basel, Switzerland) vol. 9,4 (2021). doi: https://doi.org/10.3390/healthcare9040395
van de Loo AJ, Raasveld SJ, Hogewoning A, Zeeuw R, Bosma ER, Bouwmeester NH, Lukkes M, Knipping K, Mackus M, Kraneveld AD, Brookhuis KA, Garssen J, Scholey A, Verster JC. Immune Responses after Heavy Alcohol Consumption: Cytokine Concentrations in Hangover-Sensitive and Hangover-Resistant Drinkers. Healthcare (Basel). 2021 Apr 01;9(4). doi: 10.3390/healthcare9040395. PMID: 33916085; PMCID: PMC8067124.
Copy Download .nbib Format: NLM
Share it on

Healthcare (Basel). 2021 Apr 01;9(4). doi: 10.3390/healthcare9040395.

Immune Responses after Heavy Alcohol Consumption: Cytokine Concentrations in Hangover-Sensitive and Hangover-Resistant Drinkers.

Healthcare (Basel, Switzerland)

Aurora Jae van de Loo, S Jorinde Raasveld, Anna Hogewoning, Raymond de Zeeuw, Else R Bosma, Noor H Bouwmeester, Melanie Lukkes, Karen Knipping, Marlou Mackus, Aletta D Kraneveld, Karel A Brookhuis, Johan Garssen, Andrew Scholey, Joris C Verster

Affiliations

  1. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, 3584CG Utrecht, The Netherlands.
  2. Global Centre of Excellence Immunology, Nutricia Danone Research, 3584CT Utrecht, The Netherlands.
  3. Faculty of Behavioral and Social Sciences, Groningen University, 9700AB Groningen, The Netherlands.
  4. Centre for Human Psychopharmacology, Swinburne University, Melbourne, VIC 3122, Australia.

PMID: 33916085 PMCID: PMC8067124 DOI: 10.3390/healthcare9040395

Abstract

This study investigated immunological changes during an alcohol hangover, and the possible difference between hangover-resistant and hangover-sensitive drinkers in terms of immune reactivity. Using a semi-naturalistic design, N = 36 healthy social drinkers (18 to 30 years old) provided saliva samples on a control day (after drinking no alcohol) and on a post-alcohol day. Hangover severity was rated directly after saliva collection. Cytokine concentrations, interleukin (IL)-1β, IL-6, IL-8, IL-10 and tumor necrosis factor (TNF)-α, and hangover severity were compared between both test days and between hangover-sensitive and -resistant drinkers. Data from N = 35 drinkers (17 hangover-sensitive and 18 hangover-resistant) were included in the statistical analyses. Relative to the control day, there were significant increases in saliva IL-6 and IL-10 concentrations on the post-alcohol day. No significant differences in cytokine concentrations were found between hangover-sensitive and hangover-resistant drinkers, nor did any change in cytokine concentration correlate significantly with hangover severity. In line with previous controlled studies assessing cytokines in blood, the current naturalistic study using saliva samples also demonstrated that the immune system responds to high-level alcohol intake. However, further research is warranted, as, in contrast to previous findings in blood samples, changes in saliva cytokine concentrations did not differ significantly between hangover-sensitive and hangover-resistant drinkers, nor did they correlate significantly with hangover severity.

Keywords: alcohol; cytokine; hangover; hangover severity; immune system

References

  1. Alcohol. 2017 Mar;59:37-41 - PubMed
  2. J Stud Alcohol. 1981 Jul;42(7):547-56 - PubMed
  3. Brain Behav Immun. 2011 May;25(4):640-6 - PubMed
  4. Ther Drug Monit. 1994 Oct;16(5):437-43 - PubMed
  5. Psychol Rev. 1998 Jan;105(1):83-107 - PubMed
  6. Psychopharmacology (Berl). 2017 Jan;234(1):73-77 - PubMed
  7. Alcohol Alcohol. 2012 May-Jun;47(3):248-52 - PubMed
  8. Subst Abuse Rehabil. 2016 Nov 17;7:161-167 - PubMed
  9. Curr Drug Abuse Rev. 2010 Jun;3(2):68-75 - PubMed
  10. Alcohol Alcohol. 2006 Jan-Feb;41(1):54-60 - PubMed
  11. Mediators Inflamm. 2016;2016:3758590 - PubMed
  12. J Clin Med. 2020 Mar 13;9(3): - PubMed
  13. J Clin Med. 2019 Aug 27;8(9): - PubMed
  14. Alcohol Alcohol. 2019 May 1;54(3):196-203 - PubMed
  15. Hum Psychopharmacol. 2017 Sep;32(5): - PubMed
  16. Curr Drug Abuse Rev. 2010 Jun;3(2):88-91 - PubMed
  17. J Ethnopharmacol. 2017 Sep 14;209:167-174 - PubMed
  18. Drug Alcohol Depend. 2018 Apr 1;185:351-355 - PubMed
  19. J Immunol Res. 2014;2014:614529 - PubMed
  20. Dev Psychobiol. 2014 May;56(4):797-811 - PubMed
  21. Psychopharmacology (Berl). 2014 Aug;231(15):2999-3008 - PubMed
  22. Addict Behav Rep. 2017 Jan 09;5:14-18 - PubMed
  23. Curr Drug Abuse Rev. 2008 Jan;1(1):42-6 - PubMed
  24. Brain Behav Immun. 2007 Feb;21(2):153-60 - PubMed
  25. Biomed Res Int. 2019 Jan 14;2019:3687416 - PubMed
  26. Int J Environ Res Public Health. 2020 Jun 17;17(12): - PubMed
  27. J Med Food. 2018 Nov;21(11):1188-1196 - PubMed
  28. Brain Res Mol Brain Res. 1994 Nov;27(1):63-70 - PubMed
  29. Alcohol Res. 2015;37(2):185-97 - PubMed
  30. Hum Psychopharmacol. 2017 Sep;32(5): - PubMed
  31. J Clin Med. 2020 Jul 02;9(7): - PubMed
  32. Alcohol. 2015 Feb;49(1):57-64 - PubMed
  33. Curr Drug Abuse Rev. 2017;9(2):93-98 - PubMed
  34. Curr Drug Abuse Rev. 2013;6(4):253-4 - PubMed
  35. J Clin Med. 2020 Aug 01;9(8): - PubMed
  36. J Clin Med. 2020 Mar 18;9(3): - PubMed
  37. Alcohol Clin Exp Res. 2018 Apr;42(4):691-697 - PubMed
  38. Hum Psychopharmacol. 2009 Jun;24(4):259-67 - PubMed
  39. J Clin Med. 2020 Oct 25;9(11): - PubMed
  40. J Clin Med. 2020 May 12;9(5): - PubMed
  41. J Clin Med. 2019 Dec 31;9(1): - PubMed
  42. J Clin Med. 2019 Dec 06;8(12): - PubMed
  43. Ann N Y Acad Sci. 1998 May 1;840:586-90 - PubMed
  44. J Clin Med. 2020 Aug 31;9(9): - PubMed
  45. Sci Rep. 2018 Feb 14;8(1):3031 - PubMed
  46. Alcohol. 2003 Nov;31(3):167-70 - PubMed
  47. J Prosthodont Res. 2013 Jan;57(1):51-6 - PubMed
  48. Brain Behav Immun. 2003 Apr;17(2):69-85 - PubMed
  49. Curr Drug Abuse Rev. 2017;9(2):148-154 - PubMed

Publication Types