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Sabat MJ, Wiśniewska-Becker AM, Markiewicz M, et al. Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes. Membranes (Basel). 2021;11(5)doi: 10.3390/membranes11050327.
Sabat, M. J., Wiśniewska-Becker, A. M., Markiewicz, M., Marzec, K. M., Dybas, J., Furso, J., Pabisz, P., Duda, M., & Pawlak, A. M. (2021). Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes. Membranes, 11(5), . https://doi.org/10.3390/membranes11050327
Sabat, Michał J, et al. "Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes." Membranes vol. 11,5 (2021). doi: https://doi.org/10.3390/membranes11050327
Sabat MJ, Wiśniewska-Becker AM, Markiewicz M, Marzec KM, Dybas J, Furso J, Pabisz P, Duda M, Pawlak AM. Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes. Membranes (Basel). 2021 Apr 29;11(5). doi: 10.3390/membranes11050327. PMID: 33946822; PMCID: PMC8146903.
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Membranes (Basel). 2021 Apr 29;11(5). doi: 10.3390/membranes11050327.

Tauroursodeoxycholic Acid (TUDCA)-Lipid Interactions and Antioxidant Properties of TUDCA Studied in Model of Photoreceptor Membranes.

Membranes

Michał J Sabat, Anna M Wiśniewska-Becker, Michał Markiewicz, Katarzyna M Marzec, Jakub Dybas, Justyna Furso, Paweł Pabisz, Mariusz Duda, Anna M Pawlak

Affiliations

  1. Department of Biophysics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
  2. Department of Computational Biophysics and Bioinformatics, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.
  3. Jagiellonian Centre for Experimental Therapeutics, Jagiellonian University, 30-348 Krakow, Poland.

PMID: 33946822 PMCID: PMC8146903 DOI: 10.3390/membranes11050327

Abstract

Tauroursodeoxycholic acid (TUDCA), a hydrophilic bile acid containing taurine conjugated with the ursodeoxycholic acid (UDCA), has been known and used from ancient times as a therapeutic compound in traditional Chinese medicine. TUDCA has recently been gaining significant interest as a neuroprotective agent, also exploited in the visual disorders. Among several mechanisms of TUDCA's protective action, its antioxidant activity and stabilizing effect on mitochondrial and plasma membranes are considered. In this work we investigated antioxidant activity of TUDCA and its impact on structural properties of model membranes of different composition using electron paramagnetic resonance spectroscopy and the spin labeling technique. Localization of TUDCA molecules in a pure POPC bilayer has been studied using a molecular dynamics simulation (MD). The obtained results indicate that TUDCA is not an efficient singlet oxygen (

Keywords: antioxidant; bile acids; electron paramagnetic resonance; lipid peroxidation; liposome; photoreceptor membrane

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