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Spencer PS, Chen X. The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin. Toxics. 2021;9(5)doi: 10.3390/toxics9050098.
Spencer, P. S., & Chen, X. (2021). The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin. Toxics, 9(5), . https://doi.org/10.3390/toxics9050098
Spencer, Peter S, and Chen, Xiao. "The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin." Toxics vol. 9,5 (2021). doi: https://doi.org/10.3390/toxics9050098
Spencer PS, Chen X. The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin. Toxics. 2021 Apr 29;9(5). doi: 10.3390/toxics9050098. PMID: 33946924; PMCID: PMC8146965.
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Toxics. 2021 Apr 29;9(5). doi: 10.3390/toxics9050098.

The Role of Protein Adduction in Toxic Neuropathies of Exogenous and Endogenous Origin.

Toxics

Peter S Spencer, Xiao Chen

Affiliations

  1. Department of Neurology, School of Medicine, and Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR 97239, USA.
  2. Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Subject of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.

PMID: 33946924 PMCID: PMC8146965 DOI: 10.3390/toxics9050098

Abstract

The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

Keywords: advanced glycation end product; aging; amino acid pyrrolation; central-peripheral distal axonopathy; diabetic neuropathy; protein cross-linking; uremic neuropathy; γ-diketone

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